CAJ | 학술논문

目的在蛋白质相互作用网络的基础上研究慢性粒细胞白血病,进一步深入了解其发生、发展机制.方法从在线人类孟德尔遗传数据库(OMIM)中筛选慢性粒细胞白血病遗传相关基因,应用Cytoscape软件和插件Agilent Literature Search进行文本挖掘并建立慢性粒细胞白血病的蛋白质相互作用网络.应用插件Clusterviz分析作用网络中可能包含的分子复合物.基于DAVID富集分子复合物的生物学通路.结果 OMIM中慢性粒细胞白血病遗传相关基因有79个.相关蛋白质相互作用网络包含638个节点(蛋白质)、1 830条边(相互作用关系),可能包含5个分子复合物.结论分子复合物1涉及细胞因子与炎症反应、受体相互作用及细胞因子受体信号转导等生物学通路.通过对分子复合物3的分析显示出慢性粒细胞白血病有复杂的生物学行为,与其他肿瘤有广泛的相关性,为进一步阐释慢性粒细胞白血病发生、发展的机制提供了生物信息学基础.
목적 재단백질상호작용망락적기출상연구만성립세포백혈병,진일보심입료해기발생、발전궤제.방법 종재선인류맹덕이유전수거고(OMIM)중사선만성립세포백혈병유전상관기인,응용Cytoscape연건화삽건Agilent Literature Search진행문본알굴병건립만성립세포백혈병적단백질상호작용망락.응용삽건Clusterviz분석작용망락중가능포함적분자복합물.기우DAVID부집분자복합물적생물학통로.결과 OMIM중만성립세포백혈병유전상관기인유79개.상관단백질상호작용망락포함638개절점(단백질)、1 830조변(상호작용관계),가능포함5개분자복합물.결론 분자복합물1섭급세포인자여염증반응、수체상호작용급세포인자수체신호전도등생물학통로.통과대분자복합물3적분석현시출만성립세포백혈병유복잡적생물학행위,여기타종류유엄범적상관성,위진일보천석만성립세포백혈병발생、발전적궤제제공료생물신식학기출.
Objective To study on chronic myelogenous leukemia on the basis of protein interaction network to further explore its development mechanism.Methods Chronic myelogenous leukemia-related genes were screened from Online Mendelian Inheritance in Man database (OMIM) of genetic.After text mining by Cytoscape software and Agilent Literature Search,the protein interaction networks of chronic myelogenous leukemia were established.Then the molecular complexes contained in the network were analyzed by Clusterviz plug.The biological pathways of molecular complexes were enriched based on DAVID.Results There were 79 chronic myelogenous leukemia genes in OMIM.The protein-protein interaction network of chronic myelogenous leukemia contained 638 nodes,1 830 edges and maybe 5 molecular complexes.Conclusions Pathways underlying complexes 1 are involved in cytokines and inflammation,cytokines-receptor binding,cytokine receptor signaling.Complexes 3 has relation to complex biological behavior of the tumors and other broad relevance,which can provide the bioinformatic foundation for further understanding the development mechanisms of chronic myelogenous leukemia.