国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
International Journal of Dermatology and Venereology
2015年
5期
322-325
,共4页
药疹%嗜酸粒细胞增多%症状和体征%超敏反应%疱疹病毒科感染%HLA抗原%诊断
藥疹%嗜痠粒細胞增多%癥狀和體徵%超敏反應%皰疹病毒科感染%HLA抗原%診斷
약진%기산립세포증다%증상화체정%초민반응%포진병독과감염%HLA항원%진단
Drug eruptions%Eosinophilia%Symptoms & signs%Hypersensitivity%Herpesviridae infections%HLA antigens%Diagnosis
药疹伴嗜酸性粒细胞增多和系统症状,是一种特异性的严重的药物不良反应,临床表现为皮疹、发热、淋巴结炎及内脏系统受累(包括肝炎、心肌炎、肾炎、肺炎等).目前为止其发病机制尚不确切,可能与多种因素有关,包括药物代谢途径、病毒感染与激活、免疫反应及遗传等.由于初发症状的非特异性,正确的诊断和治疗往往被延迟,其死亡率高达10％ ～ 20％.及早诊断并停药是治疗的关键,糖皮质激素、静脉注射免疫球蛋白等综合治疗能够降低药疹伴嗜酸性粒细胞增多和系统症状患者死亡率.
藥疹伴嗜痠性粒細胞增多和繫統癥狀,是一種特異性的嚴重的藥物不良反應,臨床錶現為皮疹、髮熱、淋巴結炎及內髒繫統受纍(包括肝炎、心肌炎、腎炎、肺炎等).目前為止其髮病機製尚不確切,可能與多種因素有關,包括藥物代謝途徑、病毒感染與激活、免疫反應及遺傳等.由于初髮癥狀的非特異性,正確的診斷和治療往往被延遲,其死亡率高達10％ ～ 20％.及早診斷併停藥是治療的關鍵,糖皮質激素、靜脈註射免疫毬蛋白等綜閤治療能夠降低藥疹伴嗜痠性粒細胞增多和繫統癥狀患者死亡率.
약진반기산성립세포증다화계통증상,시일충특이성적엄중적약물불량반응,림상표현위피진、발열、림파결염급내장계통수루(포괄간염、심기염、신염、폐염등).목전위지기발병궤제상불학절,가능여다충인소유관,포괄약물대사도경、병독감염여격활、면역반응급유전등.유우초발증상적비특이성,정학적진단화치료왕왕피연지,기사망솔고체10％ ～ 20％.급조진단병정약시치료적관건,당피질격소、정맥주사면역구단백등종합치료능구강저약진반기산성립세포증다화계통증상환자사망솔.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe specific adverse drug reaction clinically characterized by rashes,fever,lymphadenitis and internal organ involvement (including hepatitis,myocarditis,nephritis,pneumonitis,and so on).So far,its pathogenesis has remained unclear,and may be related to various factors,including drug metabolism pathways,viral infection and activation,immune responses and inheritance.Due to the non-specificity of initial symptoms,correct diagnosis and treatment of DRESS are often delayed,with a mortality rate of up to 10％-20％.Early diagnosis and drug withdrawal are the key to its treatment.Comprehensive therapy with glucocorticoids and intravenous immunoglobulin (IVIG) can reduce the mortality of patients with DRESS.
