CAJ | 학술논문

【目的】探讨CYP1A2*1F基因多态性与肺癌易感性之间的关系。【方法】收集CYPlA2163A／C基因多态性与肺癌易感性文献6篇，累计肺癌病例1033例，对照1626例，应用Meta分析探讨CYP1A2*1F基因多态性与肺癌易感性之间的关系。【结果】CYP1A2*1F基因多态性中CC vs AA的OR值为1．04，95％可信区间为0．54～2．02；AC vs AA的OR值为0．85，95％可信区间为，0．61～1．20；CC ＋ AC vs AA的OR值为0．88，95％可信区间为0．60～1．27；CC vs AA ＋ AC的OR值为0．83；95％可信区间为0．54～1．28。【结论】CYP1A2*1F基因多态性不增加肺癌的患病风险。
【목적】탐토CYP1A2*1F기인다태성여폐암역감성지간적관계。【방법】수집CYPlA2163A／C기인다태성여폐암역감성문헌6편，루계폐암병례1033례，대조1626례，응용Meta분석탐토CYP1A2*1F기인다태성여폐암역감성지간적관계。【결과】CYP1A2*1F기인다태성중CC vs AA적OR치위1．04，95％가신구간위0．54～2．02；AC vs AA적OR치위0．85，95％가신구간위，0．61～1．20；CC ＋ AC vs AA적OR치위0．88，95％가신구간위0．60～1．27；CC vs AA ＋ AC적OR치위0．83；95％가신구간위0．54～1．28。【결론】CYP1A2*1F기인다태성불증가폐암적환병풍험。
[Objective] To explore the relationship between CYPlA2 163A/C polymorphism and individual susceptibility of lung cancer .[Methods] Six studies involving 1 ,033 cases and 1 ,626 controls were retrieved . And meta‐analysis was conducted .[Results] The analysis for homogeneity (Q statistics test) showed that all eligible studies conformed to homogeneity .For CC vs AA ,the odds ratio (OR) was 1 .04 (95% CI= 0 .54~2 .02);for AC vs AA ,the OR 0 .85 (95% CI=0 .61~1 .20);for CC+ AC vs AA ,the OR 0 .88(95% CI=0 .60~1 .27);for CC vs AA+AC ,the OR 0 .83(95% CI=0 .54~1 .28) .[Conclusion]CYPlA2 163A/C poly‐morphism is not a risk factor for higher susceptibility of lung cancer .