中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
17期
44-45
,共2页
稳心颗粒%阿托伐他汀%不稳定型心绞痛
穩心顆粒%阿託伐他汀%不穩定型心絞痛
은심과립%아탁벌타정%불은정형심교통
Wenxin Granules%atorvastatin%UAP
目的：探讨稳心颗粒联合阿托伐他汀治疗不稳定型心绞痛（unstale angina Pectoris，UAP）的疗效及对患者血液流变学的影响。方法将180例符合纳入标准的UAP患者随机分为2组，各90例。两组均给予低流量持续吸氧、阿司匹林、倍他乐克及钙拮抗剂等常规治疗。对照组在常规治疗基础上给予阿托伐他汀治疗；观察组在对照组的基础上联合使用稳心颗粒治疗。比较2组UAP患者疗效， UAP发生频率及持续时间，红细胞压积、全血黏度及纤维蛋白原等血液流变学指标。结果观察组的治疗总有效率为96.67％，明显高于对照组的86.67％（ P＜0.05）。相对于治疗前，两组患者UAP发生频率及持续时间减少，红细胞压积、全血黏度及纤维蛋白原等血液流变学指标均下降（ P＜0.05）。与对照组相比，观察组治疗后UAP发生频率及持续时间显著减少，血液流变学指标显著下降，比较均有统计学差异（ P＜0.05）。结论稳心颗粒联合阿托伐他汀治疗UAP疗效显著，可提高治疗有效率，减少UAP发生频率及持续时间，并显著降低红细胞压积、全血黏度及纤维蛋白原等血液流变学指标，值得进一步研究。
目的：探討穩心顆粒聯閤阿託伐他汀治療不穩定型心絞痛（unstale angina Pectoris，UAP）的療效及對患者血液流變學的影響。方法將180例符閤納入標準的UAP患者隨機分為2組，各90例。兩組均給予低流量持續吸氧、阿司匹林、倍他樂剋及鈣拮抗劑等常規治療。對照組在常規治療基礎上給予阿託伐他汀治療；觀察組在對照組的基礎上聯閤使用穩心顆粒治療。比較2組UAP患者療效， UAP髮生頻率及持續時間，紅細胞壓積、全血黏度及纖維蛋白原等血液流變學指標。結果觀察組的治療總有效率為96.67％，明顯高于對照組的86.67％（ P＜0.05）。相對于治療前，兩組患者UAP髮生頻率及持續時間減少，紅細胞壓積、全血黏度及纖維蛋白原等血液流變學指標均下降（ P＜0.05）。與對照組相比，觀察組治療後UAP髮生頻率及持續時間顯著減少，血液流變學指標顯著下降，比較均有統計學差異（ P＜0.05）。結論穩心顆粒聯閤阿託伐他汀治療UAP療效顯著，可提高治療有效率，減少UAP髮生頻率及持續時間，併顯著降低紅細胞壓積、全血黏度及纖維蛋白原等血液流變學指標，值得進一步研究。
목적：탐토은심과립연합아탁벌타정치료불은정형심교통（unstale angina Pectoris，UAP）적료효급대환자혈액류변학적영향。방법장180례부합납입표준적UAP환자수궤분위2조，각90례。량조균급여저류량지속흡양、아사필림、배타악극급개길항제등상규치료。대조조재상규치료기출상급여아탁벌타정치료；관찰조재대조조적기출상연합사용은심과립치료。비교2조UAP환자료효， UAP발생빈솔급지속시간，홍세포압적、전혈점도급섬유단백원등혈액류변학지표。결과관찰조적치료총유효솔위96.67％，명현고우대조조적86.67％（ P＜0.05）。상대우치료전，량조환자UAP발생빈솔급지속시간감소，홍세포압적、전혈점도급섬유단백원등혈액류변학지표균하강（ P＜0.05）。여대조조상비，관찰조치료후UAP발생빈솔급지속시간현저감소，혈액류변학지표현저하강，비교균유통계학차이（ P＜0.05）。결론은심과립연합아탁벌타정치료UAP료효현저，가제고치료유효솔，감소UAP발생빈솔급지속시간，병현저강저홍세포압적、전혈점도급섬유단백원등혈액류변학지표，치득진일보연구。
Objective To investigate the clinical effect of Wenxin Granules combined with atorvastatin in treating Patients with unstable angina Pectoris ( UAP ) and its effect on hemorheological Parameters. Methods 180 cases of UAP meeting the inclusion critera were randomly divided into 2 grouPs,90 cases in each grouP. Besides conventional treatments,the control grouP were treated with atorvastatin and the observation grouP were treated with Wenxin Grannles combined with atorvastatin. The curative efficacy,seizure frequency and the duration of UAP and hemorheological Parameters were observed and comPared. Results The observation grouP had a total theraPeutic efficiency ratio ( TER ) of 96. 67%,which was significantly higher than 86. 67% in the control grouP ( P < 0. 05 ) . ComPared with those before treatment ,the seizure frequency and the duration of UAP and the hemorheological Parameters were all reduced after treatment ( P < 0. 05 ) ,and these indices decreased more significantly in the observation grouP ( P < 0. 05 ) . Conclusion Combined treatment of Wenxin Granules with atorvastatin for UAP theraPy was effective,which could increase the theraPeutic efficiency ratio,significantly de-crease the seizure frequency and the duration of UAP,and reduce hemorheological Parameters.
