CAJ | 학술논문

肝癌是常见恶性肿瘤之一，其发病机制尚未完全阐明，建立动物肝癌模型为阐明机制提供理论基础。与移植模型、细胞模型相比，诱发性大鼠肝癌模型接近于人肝癌的发病过程，更适合于对于药物机制的研究，其中solt farber模型具有造模时间短、动物死亡率低、方法灵活等优势。对诱发性大鼠肝癌模型的研究进展进行综述。
간암시상견악성종류지일，기발병궤제상미완전천명，건립동물간암모형위천명궤제제공이론기출。여이식모형、세포모형상비，유발성대서간암모형접근우인간암적발병과정，경괄합우대우약물궤제적연구，기중solt farber모형구유조모시간단、동물사망솔저、방법령활등우세。대유발성대서간암모형적연구진전진행종술。
Hepatocellular carcinoma is one of the common tumors , but the mechanism of liver cancer has not been fully elucidated .Establishing an animal model of liver cancer can pro-vide theoretical foundation for clarifying the mechanism of liver cancer .Comparing with transplantation model and cell model , chemically induced hepatocellular carcinoma rats mod-el is similar to the pathogenesis of human hepatocellular carcinoma , which fits the study of drug mechanisms more .among them the solt farber model has the advantages of short-time, low animal mortality and flexible approach .This paper discussed the progress of rat -in-duced liver cancer model .