CAJ | 학술논문

研究乳化溶液挥发法制备马钱子总生物碱药物树脂复合物包衣的最佳处方．以司盘－80、石蜡和乙醇为乳化体系，乙基纤维素为囊材，聚乙二醇－400为致孔剂，邻苯二甲酸二乙酯为增塑剂，采用星点效应实验设计联合应用优化处方．马钱子总生物碱树脂复合物的最佳微囊包衣处方用量为：乙基纤维素为11．68％，聚乙二醇－400为3．17％，邻苯二甲酸二乙酯为11．83％，在石蜡∶司盘－80∶无水乙醇＝30∶3∶4的乳化体系中，在35℃、500 r／min的磁力搅拌条件下搅拌至无醇味．采用正交试验和星点效应联合实验设计筛选的最优处方，制备的马钱子总生物碱树脂复合物微囊外形好，释放度较高．
연구유화용액휘발법제비마전자총생물감약물수지복합물포의적최가처방．이사반－80、석사화을순위유화체계，을기섬유소위낭재，취을이순－400위치공제，린분이갑산이을지위증소제，채용성점효응실험설계연합응용우화처방．마전자총생물감수지복합물적최가미낭포의처방용량위：을기섬유소위11．68％，취을이순－400위3．17％，린분이갑산이을지위11．83％，재석사∶사반－80∶무수을순＝30∶3∶4적유화체계중，재35℃、500 r／min적자력교반조건하교반지무순미．채용정교시험화성점효응연합실험설계사선적최우처방，제비적마전자총생물감수지복합물미낭외형호，석방도교고．
To study the best coating prescription of Strychnos nux -vomica total alkaloid drug-resin complex with emulsifying solution evaporation method the experiment design of cen -tral composite design combined with response surface method were selected to determine the optimum formulation with span -80 , paraffin and ethanol as emulsifying system , ethyl cellu-lose as microcapsule material , polyethylene glycol-400 as porogen, and diethyl phthalate as plasticizers in this prescription .In microcapsule coating prescription , the best dosage ratio of Strychnos nux-vomica total alkaloid drug -resin complex was 11.68% ( ethyl cellulose ) , 3.17%(polyethylene glycol -400), and 11.83% (diethyl phthalate) under the emulsif-ying system of paraffin, span-80 and ethyl alcohol (30∶3∶4).The process stopped tills no taste of alcohol with magnetic stirring of 500 r/min and temperature of 35℃.By the method of orthogonal design and experimental design of central composite design combined with re-sponse surface method to select the optimum formulation , Strychnos nux-vomica total alka-loid drug-resin complex microcapsules were with good shape and high release .