中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
17期
31-32
,共2页
脓毒血症%扶正败毒颗粒%免疫功能%疗效
膿毒血癥%扶正敗毒顆粒%免疫功能%療效
농독혈증%부정패독과립%면역공능%료효
sePsis%Fuzhengbaidu Granule%immune function%curative effect
目的：探讨加用扶正败毒颗粒对改善脓毒血症患者免疫功能的疗效并评价其安全性。方法将脓毒血症患者58例随机分为对照组和观察组，各29例。对照组患者予以常规治疗，观察组患者在此基础上加用扶正败毒颗粒。结果两组患者治疗后急性生理与慢性健康（APACHE－Ⅱ）评分均显著低于治疗前（ P＜0.05），而组间未见明显差异。对照组患者治疗后 CD3及CD4/CD8均较前明显下降（ P＜0.05），而同期观察组患者与治疗前相比，CD3，CD4及CD4/CD8均明显升高（ P＜0.05）。两组患者治疗前血清白细胞介素－10( IL－10)及肿瘤坏死因子－α( TNF－α)均显著高于正常水平，且观察组患者治疗后IL－10及TNF－α均显著低于治疗前水平（ P＜0.05）。组间不良反应发生率比较无显著性差异（ P＞0.05）。结论加用扶正败毒颗粒对于改善脓毒血症患者免疫功能安全、有效。
目的：探討加用扶正敗毒顆粒對改善膿毒血癥患者免疫功能的療效併評價其安全性。方法將膿毒血癥患者58例隨機分為對照組和觀察組，各29例。對照組患者予以常規治療，觀察組患者在此基礎上加用扶正敗毒顆粒。結果兩組患者治療後急性生理與慢性健康（APACHE－Ⅱ）評分均顯著低于治療前（ P＜0.05），而組間未見明顯差異。對照組患者治療後 CD3及CD4/CD8均較前明顯下降（ P＜0.05），而同期觀察組患者與治療前相比，CD3，CD4及CD4/CD8均明顯升高（ P＜0.05）。兩組患者治療前血清白細胞介素－10( IL－10)及腫瘤壞死因子－α( TNF－α)均顯著高于正常水平，且觀察組患者治療後IL－10及TNF－α均顯著低于治療前水平（ P＜0.05）。組間不良反應髮生率比較無顯著性差異（ P＞0.05）。結論加用扶正敗毒顆粒對于改善膿毒血癥患者免疫功能安全、有效。
목적：탐토가용부정패독과립대개선농독혈증환자면역공능적료효병평개기안전성。방법장농독혈증환자58례수궤분위대조조화관찰조，각29례。대조조환자여이상규치료，관찰조환자재차기출상가용부정패독과립。결과량조환자치료후급성생리여만성건강（APACHE－Ⅱ）평분균현저저우치료전（ P＜0.05），이조간미견명현차이。대조조환자치료후 CD3급CD4/CD8균교전명현하강（ P＜0.05），이동기관찰조환자여치료전상비，CD3，CD4급CD4/CD8균명현승고（ P＜0.05）。량조환자치료전혈청백세포개소－10( IL－10)급종류배사인자－α( TNF－α)균현저고우정상수평，차관찰조환자치료후IL－10급TNF－α균현저저우치료전수평（ P＜0.05）。조간불량반응발생솔비교무현저성차이（ P＞0.05）。결론가용부정패독과립대우개선농독혈증환자면역공능안전、유효。
Objective To investigate the efficacy of Fuzhengbaidu Granule for imProving the immune function of Patients with sePsis and to evaluate its safety. Methods 58 cases of Patients with sePsis were randomly divided into the control grouP and the observation grouP, 29 cases in each grouP. The control grouP received routine treatment, and the observation grouP received Fuzhengbaidu Granule on the basis of the control grouP. Results After treatment, the APACHE-II scores of the two grouPs were both significantly lower than those before treatment ( P < 0. 05 ) , with no significant difference between the two grouPs. The CD3, CD4/CD8 of the control grouP were significantly decreased ( P < 0. 05 ) , while during the same Period, CD3, CD4 and CD4/CD8 of the observation grouP increased signifi-cantly ( P < 0. 05 ) . Serum levels of IL-10 and TNF- α level of the two grouPs were significantly higher than the normal level, but the IL-10 and TNF-α of the observation grouP were significantly lower than those before treatment ( P < 0. 05 ) . The occurrence rate of the adverse reactions between the two grouPs had no significant difference ( P > 0. 05 ) . Conclusion Adding Fuzhengbaidu Grandule for imProving the immune function in Patients with sePsis is safe and effective.
