中国伤残医学
中國傷殘醫學
중국상잔의학
Chinese Journal of Trauma and Disability Medicine
2015年
17期
28-29,30
,共3页
帕利哌酮缓释片%阿立哌唑口腔崩解片%精神分裂症
帕利哌酮緩釋片%阿立哌唑口腔崩解片%精神分裂癥
파리고동완석편%아립고서구강붕해편%정신분렬증
Paliperidone extended-release tablets%Aripiprazole orally disintegrating tablets%Schizophrenia
目的：对比帕利哌酮缓释片与阿立哌唑口腔崩解片治疗精神分裂症的疗效及安全性。方法：将符合入组标准的69例精神分裂症患者随机分为帕利哌酮缓释片组（研究组）35例及阿立哌唑口腔崩解片组（对照组）34例，在治疗前及第4、8周末，用阳性和阴性症状量表（ PANSS）评定疗效，用副反应量表（ TESS）评定不良反应。结果：共完成62例，研究组32例，对照组30例。治疗8周末，研究组有效率93．8％，对照组有效率90．0％，2组比较差异无统计学意义（x2＝0．29，P＝0．667）。2组在治疗第4、8周末时PANSS总分及阳性症状、阴性症状、精神病性症状评分较治疗前均减少（ Ps＜0．05）。在治疗4周末时，研究组阴性症状分下降较对照组明显（t＝2．20，P＝0．032）；治疗8周末时，研究组阴性症状分下降也较对照组明显（t＝2．08，P＝0．042），2组不良反应发生率差异无统计学意义（x2＝1．00，P＝0．316）。结论：帕利哌酮缓释片和阿立哌唑口腔崩解片对精神分裂症疗效相当，且帕利哌酮缓释片对阴性症状有较好的疗效。
目的：對比帕利哌酮緩釋片與阿立哌唑口腔崩解片治療精神分裂癥的療效及安全性。方法：將符閤入組標準的69例精神分裂癥患者隨機分為帕利哌酮緩釋片組（研究組）35例及阿立哌唑口腔崩解片組（對照組）34例，在治療前及第4、8週末，用暘性和陰性癥狀量錶（ PANSS）評定療效，用副反應量錶（ TESS）評定不良反應。結果：共完成62例，研究組32例，對照組30例。治療8週末，研究組有效率93．8％，對照組有效率90．0％，2組比較差異無統計學意義（x2＝0．29，P＝0．667）。2組在治療第4、8週末時PANSS總分及暘性癥狀、陰性癥狀、精神病性癥狀評分較治療前均減少（ Ps＜0．05）。在治療4週末時，研究組陰性癥狀分下降較對照組明顯（t＝2．20，P＝0．032）；治療8週末時，研究組陰性癥狀分下降也較對照組明顯（t＝2．08，P＝0．042），2組不良反應髮生率差異無統計學意義（x2＝1．00，P＝0．316）。結論：帕利哌酮緩釋片和阿立哌唑口腔崩解片對精神分裂癥療效相噹，且帕利哌酮緩釋片對陰性癥狀有較好的療效。
목적：대비파리고동완석편여아립고서구강붕해편치료정신분렬증적료효급안전성。방법：장부합입조표준적69례정신분렬증환자수궤분위파리고동완석편조（연구조）35례급아립고서구강붕해편조（대조조）34례，재치료전급제4、8주말，용양성화음성증상량표（ PANSS）평정료효，용부반응량표（ TESS）평정불량반응。결과：공완성62례，연구조32례，대조조30례。치료8주말，연구조유효솔93．8％，대조조유효솔90．0％，2조비교차이무통계학의의（x2＝0．29，P＝0．667）。2조재치료제4、8주말시PANSS총분급양성증상、음성증상、정신병성증상평분교치료전균감소（ Ps＜0．05）。재치료4주말시，연구조음성증상분하강교대조조명현（t＝2．20，P＝0．032）；치료8주말시，연구조음성증상분하강야교대조조명현（t＝2．08，P＝0．042），2조불량반응발생솔차이무통계학의의（x2＝1．00，P＝0．316）。결론：파리고동완석편화아립고서구강붕해편대정신분렬증료효상당，차파리고동완석편대음성증상유교호적료효。
Objective:To study the efficacy and safety in the treatment of schizophrenia between Paliperidone extended-release tab-lets and aripiprazole orally disintegrating tablets.Methods:There were 69 cases of schizophrenia patients who accord with the criteria, they were randomized to study group which 35 cases of paliperidone extended-release tablets and control group which 34 cases of aripi-prazole orally disintegrating tablets.Among the pre-treatment、the medication four weeks and eight weeks,the efficacy was evaluated with positive and negative syndrome scale ( PANSS) , adverse reaction was assessed by Treatment Emergent Symptom Scale( TESS) .Results:A total of 62 cases completed which the 32 cases study group and the 30 cases control group.After 8 weeks of treatment, study group effi-cacy was 93.8%, the control group efficacy was 90.0%, the difference was not statistically significant (χ2=0.29,P=0.667) .After the medication four weeks and eight weeks , the PANSS scores, positive symptoms scores, negative symptoms scores, psychotic symptoms scores were reduced which compared with pre-treatment(Ps<0.05=.After the medication four weeks and eight weeks, negative symp-toms scores from the study group decreased more significantly than the control group respectively (t =2.20, P =0.032)(t =2.08, P=0.042 ), adverse reaction was no significant difference from two groups (x2 =1.00,P=0.316).Conclusion:The efficacy of Paliper-idone extended-release tablets and aripiprazole orally disintegrating tablets for Schizophrenia was fairly, and Paliperidone extended-re-lease tablets to negative symptoms have better effect.
