CAJ | 학술논문

目的：观察多西他赛联合洛铂化疗方案治疗老年晚期卵巢癌的临床疗效及其安全性。方法：老年晚期卵巢癌合并腹水患者32例，以多西他赛联合洛铂方案（ TL方案）进行化疗：第1天多西他赛75 mg／m2静脉滴注、洛铂30 mg／m2加入葡萄糖溶液溶解后腹腔内注入化疗，21天为1周期，治疗2个周期后进行评价。结果：总有效率46．9％，其中Ⅲ期、Ⅳ期有效率分别为52．4％、36．4％，差异具有统计学意义（P＝0．048＜0．05）；浆液性和黏液性卵巢癌有效率分别为47．4％和46．2％，差异无统计学意义（P＝0．121＞0．05）。毒副反应较轻，以Ⅰ～Ⅱ度骨髓抑制为主。结论：TL方案治疗老年晚期卵巢癌疗效好，经对症处理，毒副反应患者可耐受，且有较好的依从性，可作为一线方案使用。
목적：관찰다서타새연합락박화료방안치료노년만기란소암적림상료효급기안전성。방법：노년만기란소암합병복수환자32례，이다서타새연합락박방안（ TL방안）진행화료：제1천다서타새75 mg／m2정맥적주、락박30 mg／m2가입포도당용액용해후복강내주입화료，21천위1주기，치료2개주기후진행평개。결과：총유효솔46．9％，기중Ⅲ기、Ⅳ기유효솔분별위52．4％、36．4％，차이구유통계학의의（P＝0．048＜0．05）；장액성화점액성란소암유효솔분별위47．4％화46．2％，차이무통계학의의（P＝0．121＞0．05）。독부반응교경，이Ⅰ～Ⅱ도골수억제위주。결론：TL방안치료노년만기란소암료효호，경대증처리，독부반응환자가내수，차유교호적의종성，가작위일선방안사용。
Objective:To evaluate the effects and safety of docetaxel and lobaplatin on treating elderly advanced ovarian carcinoma. Methods:A total of 32 patients with recurrent elderly advanced ovarian carcinoma were enrolled.lobaplatin at a dose of 30 mg/m2 intra-venous infusion on d1, and docetaxel at a dose of75 mg/m2intravenous infusion on d 1.Every 21days was 1 cycle.The efficacy was eval-uated after 2 cycles.Results:The overall response rate (RR=CR+PR) was 46.9%.The overall response rate was 52.4%in the stageⅢpatients and 36.4%in the stageⅣpatients, the deference have statistics significance.The overall response rate was 47.4%in the in the serous ovarian cancer patients and 46.2%in the mucinous ovarian cancer patients, there were no statistical significance.The major ad-verse effects were I~II bone marrow depression.Conclusion:Combined chemotherapy of lobaplatin and docetaxel has a good anti-tumor activity and manageable toxicity on elderly advanced ovarian carcinoma patients.