中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
17期
17-18,19
,共3页
替罗非班%颅脑创伤%静脉血栓栓塞症%预防性治疗%安全性
替囉非班%顱腦創傷%靜脈血栓栓塞癥%預防性治療%安全性
체라비반%로뇌창상%정맥혈전전새증%예방성치료%안전성
tirofiban%craniocerebral traumat%venous thromboembolism%Preventive treatment%safety
目的：探讨替罗非班对颅脑创伤术后静脉血栓栓塞症的预防作用及安全性。方法将2014年1月至2015年1月收治的拟行闭合性颅脑创伤手术后住院患者130例随机分为观察组和对照组，每组65例。手术后对照组采用低分子肝素钙注射液皮下注射，观察组采用盐酸替罗非班注射液静脉泵入，疗程均为14 d。结果观察组术后静脉血栓栓塞症发生率为1.54％，低于对照组的10.77％( P＜0.05)；两组术后血栓弹力图指标反应时间(R值)、凝固时间(K值)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及凝血酶时间( TT )指标均呈现先上升后下降的趋势，血栓最大幅度( Ma值)、凝固角(α值)及 D－二聚体指变化呈现均呈先降低后逐步升高的趋势，观察组波动幅度小于对照组，变化更为平稳，术后24 h、3 d两组以上指标较术前均具有统计学意义（ P＜0.05）。观察组不良反应发生率为7.69％，低于对照组的15.38％（ P＜0.05）。结论替罗非班用于预防颅脑创伤术后静脉血栓栓塞症临床效果更显著，不影响机体凝血功能，且不良反应更少。
目的：探討替囉非班對顱腦創傷術後靜脈血栓栓塞癥的預防作用及安全性。方法將2014年1月至2015年1月收治的擬行閉閤性顱腦創傷手術後住院患者130例隨機分為觀察組和對照組，每組65例。手術後對照組採用低分子肝素鈣註射液皮下註射，觀察組採用鹽痠替囉非班註射液靜脈泵入，療程均為14 d。結果觀察組術後靜脈血栓栓塞癥髮生率為1.54％，低于對照組的10.77％( P＜0.05)；兩組術後血栓彈力圖指標反應時間(R值)、凝固時間(K值)、血漿凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)及凝血酶時間( TT )指標均呈現先上升後下降的趨勢，血栓最大幅度( Ma值)、凝固角(α值)及 D－二聚體指變化呈現均呈先降低後逐步升高的趨勢，觀察組波動幅度小于對照組，變化更為平穩，術後24 h、3 d兩組以上指標較術前均具有統計學意義（ P＜0.05）。觀察組不良反應髮生率為7.69％，低于對照組的15.38％（ P＜0.05）。結論替囉非班用于預防顱腦創傷術後靜脈血栓栓塞癥臨床效果更顯著，不影響機體凝血功能，且不良反應更少。
목적：탐토체라비반대로뇌창상술후정맥혈전전새증적예방작용급안전성。방법장2014년1월지2015년1월수치적의행폐합성로뇌창상수술후주원환자130례수궤분위관찰조화대조조，매조65례。수술후대조조채용저분자간소개주사액피하주사，관찰조채용염산체라비반주사액정맥빙입，료정균위14 d。결과관찰조술후정맥혈전전새증발생솔위1.54％，저우대조조적10.77％( P＜0.05)；량조술후혈전탄력도지표반응시간(R치)、응고시간(K치)、혈장응혈매원시간(PT)、활화부분응혈활매시간(APTT)급응혈매시간( TT )지표균정현선상승후하강적추세，혈전최대폭도( Ma치)、응고각(α치)급 D－이취체지변화정현균정선강저후축보승고적추세，관찰조파동폭도소우대조조，변화경위평은，술후24 h、3 d량조이상지표교술전균구유통계학의의（ P＜0.05）。관찰조불량반응발생솔위7.69％，저우대조조적15.38％（ P＜0.05）。결론체라비반용우예방로뇌창상술후정맥혈전전새증림상효과경현저，불영향궤체응혈공능，차불량반응경소。
Objective To observe the Preventive effect and safety of tirofiban for treating PostoPerative venous thromboembolism in Pa-tients with cerebral trauma. Methods 130 PostoPerative in Patients with cerebral trauma from January 2014 to January 2015 were ran-domly divided into the observation grouP and the control grouP,65 cases in each grouP. After oPeration,the control grouP used low molecular weight heParin calcium injection,the observing grouP selected tirofiban by intravenous infusion,the treatment course was 14d. Results The incidence of PostoPerative venous thromboembolism in the observation grouP was 1. 54%,which was lower than 10. 77%in the control grouP ( P < 0. 05 );the changes of Patients 24 h R value and K value in the observation grouP were high on PostoPer-ative 24 h and low on 3d,Ma value and alPha value were low in 24 h and high on 3d,but there were no statistically significant difference ( P > 0. 05 ) ,the changes of the TEG index in the two grouPs after 14d had no statistical difference ( P > 0. 05 );the coag-ulation function index after 3d 14d of PT,APTT and TT D-dimer had no obvious difference ( P > 0. 05 ) ,and the PostoPerative co-agulation function index and D-dimer had no difference with before oPeration ( P > 0. 05 );the incidence of adverse reactions of the observation grouP was 7. 69%,which was lower than 15. 38% in the control grouP ( P < 0. 05). Conclusion The clinical Preventive ef-fect of tirofiban for treating PostoPerative venous thromboembolism in Patients with cerebral trauma is more obvious,and it does not af-fect the coagulation function of the body with less adverse reactions.
