CAJ | 학술논문

【目的】探讨血清妊娠相关蛋白A（PAPP‐A）、胎盘生长因子（PLGF）、可溶性Fms样酪氨酸激酶1（sFlt‐1）在子痫前期患者中的表达及意义。【方法】回顾性分析本院2013年2月至2014年6月收治的82例妊娠妇女的临床资料，包括21例轻度子痫前期患者、16例重度子痫前期患者和45例正常妊娠妇女，分别于四个妊娠阶段（12～15周、20～24周、28～32周，35～37周）采用ELISA法检测患者血清中PAPP‐A、PLGF、sFlt‐1的浓度水平并比较。【结果】三组血清PAPP‐A浓度在28～32周和35～37周比较均有显著性差异（ P＜0．05）；轻度和重度子痫前期血清PLGF浓度在20～24周、28～32周、35～37周均显著低于对照组（ P ＜0．05），重度子痫前期在28～32周、35～37周显著低于轻度子痫前期（ P ＜0．05）；三组血清sFlt‐1浓度在28～32周、35～37周比较均有显著性差异（ P＜0．05）。在20～24周、28～32周、35～37周对照组、轻度子痫前期、重度子痫前期sFlt‐1／PLGF值依次升高（ P＜0．05），且组间比较有显著性差异（ P ＜0．05）。【结论】血清标志物PAPP‐A、PLGF和sFlt‐1对子痫前期诊治有较高的参考价值，sFlt‐1／PLGF更有优势。
【목적】탐토혈청임신상관단백A（PAPP‐A）、태반생장인자（PLGF）、가용성Fms양락안산격매1（sFlt‐1）재자간전기환자중적표체급의의。【방법】회고성분석본원2013년2월지2014년6월수치적82례임신부녀적림상자료，포괄21례경도자간전기환자、16례중도자간전기환자화45례정상임신부녀，분별우사개임신계단（12～15주、20～24주、28～32주，35～37주）채용ELISA법검측환자혈청중PAPP‐A、PLGF、sFlt‐1적농도수평병비교。【결과】삼조혈청PAPP‐A농도재28～32주화35～37주비교균유현저성차이（ P＜0．05）；경도화중도자간전기혈청PLGF농도재20～24주、28～32주、35～37주균현저저우대조조（ P ＜0．05），중도자간전기재28～32주、35～37주현저저우경도자간전기（ P ＜0．05）；삼조혈청sFlt‐1농도재28～32주、35～37주비교균유현저성차이（ P＜0．05）。재20～24주、28～32주、35～37주대조조、경도자간전기、중도자간전기sFlt‐1／PLGF치의차승고（ P＜0．05），차조간비교유현저성차이（ P ＜0．05）。【결론】혈청표지물PAPP‐A、PLGF화sFlt‐1대자간전기진치유교고적삼고개치，sFlt‐1／PLGF경유우세。
[Objective] To explore the expressions and significance of pregnancy‐associated plasma protein‐A (PAPP‐A) ,placental growth factor (PLGF) and soluble fms‐like tyrosine kinase receptor‐1 (sFlt‐1) in pregnant women with preeclampsia .[Methods] Retrospective analysis was performed for 82 pregnant women from February 2013 to June 2014 ,including mild preeclampsia ( n=21) ,severe preeclampsia ( n=16) and 45 normal pregnancy ( n=45) .And enzyme‐linked immunosorbent assay (ELISA) was employed to measure the serum concentrations of PAPP‐A ,PLGF and sFlt‐1 at four gestational periods of 12~15 ,20~24 ,28~32 &35~37 weeks .One way analysis of variation (ANOVA) was used to determine the differences of observation and control groups .[Results]During the first period ,all three indicators were similar ;during the second peri‐od ,sFlt‐1 and PLGF were useful for distinguishing preeclampsia group from normal group .During third and fourth periods ,these indicators were effective for distinguishing preeclampsia group from control group and se‐vere preeclampsia from mild preeclampsia .And the ratio of sFlt/PLGF was a more effective indicator for meas‐uring the difference of these groups .[Conclusion]Serum indicators ,such as PAPP‐A ,PLGF and sFlt‐1 ,are useful in the diagnosis of preeclampsia .However ,the ratio of sFlt and PLGF is more effective for diagnosing preeclampsia earlier .