CAJ | 학술논문

探究2-吲哚乙酸乙酯新的合成方法和合成工艺。以2-硝基苯乙酸和丙二酸二乙酯为原料，通过亲核加成和还原环化反应，合成2-吲哚乙酸乙酯，关键合成步骤以不同的物料比、温度和反应时间进行反应，测得最终反应的转化率和产率，得到新的合成路线和最佳合成工艺。合成的最终产物为浅棕色固体，熔点为28—31℃，利用IR、1 HNMR和MS等分析手段对中间体和终产物的结构进行了表征和分析，确认最终产物即为目标产物2-吲哚乙酸乙酯。新的合成方法反应条件温和，中间体产物无须分离，关键步骤最佳合成工艺为：物料配比n（2-硝基苯乙酸）：n（丙二酸单乙酯钾盐）为1∶2，反应温度5℃，反应时间为20 h，此时产品收率达87．5％，色谱检测纯度≥98％。
탐구2-신타을산을지신적합성방법화합성공예。이2-초기분을산화병이산이을지위원료，통과친핵가성화환원배화반응，합성2-신타을산을지，관건합성보취이불동적물료비、온도화반응시간진행반응，측득최종반응적전화솔화산솔，득도신적합성로선화최가합성공예。합성적최종산물위천종색고체，용점위28—31℃，이용IR、1 HNMR화MS등분석수단대중간체화종산물적결구진행료표정화분석，학인최종산물즉위목표산물2-신타을산을지。신적합성방법반응조건온화，중간체산물무수분리，관건보취최가합성공예위：물료배비n（2-초기분을산）：n（병이산단을지갑염）위1∶2，반응온도5℃，반응시간위20 h，차시산품수솔체87．5％，색보검측순도≥98％。
To explore the new method for synthesizing 2-indole acetic acid ethyl ester , and research the synthesis process.2-indoleacetic acid ethyl ester is synthesized by the nucleophilic addition and the reductive cyclisation re -actions using 2-nitrophenyl acetic acid and diethyl malonate as raw materials ,a new synthetic route was obtain and the best synthesis processin were optimized , through the determination of the last reaction conversion rate and yield , with different raw material ratio , reaction temperature and reaction time reaction time and temperature of reaction in the key step of synthesis .The final product synthesis is light brown solid , the melting point of about 28-31℃, by u-sing IR and 1 HNMR, MS and other analytical methods , the structure of the intermediates and the end products were characterized and analyzed , confirming the final product is the target product 2-indoleacetic acid ethyl ester .The new synthesis method has the advantages of mild reaction conditions , intermediate products do not need to be sepa-rated,and the synthesis process of the key steps is best material ratio n (2-nitrophenyl acetic acid ):n ( ethyl mal-onate potassium salt) was 1:2, reaction temperature was 5 C, reaction time was 20h, at this condition ,the yield was 87 .5%, the chromatographic purity was more than 98%.