CAJ | 학술논문

目的：分析锌对婴幼儿肺炎患儿免疫功能的影响。方法选取2014年5～7月收治的婴幼儿肺炎患儿96例随机分成锌辅助治疗组和常规治疗组，各48例。常规治疗组给予常规治疗措施，锌辅助治疗组在常规治疗的同时给予锌制剂。分别在治疗前、治疗后对两组各进行一次血清锌水平和免疫功能检测。另选取同期体检健康婴幼儿40例作为健康对照组。对3组的血清锌水平及免疫功能进行统计分析。结果治疗前两组患儿血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋／CD8＋细胞比值均低于健康对照组，CD8＋细胞百分比均高于健康对照组，差异均有统计学意义（ P＜0．05）；但两组患儿各指标比较差异均无统计学意义（P＞0．05）。锌辅助治疗组治疗后血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋／CD8＋细胞比值均高于常规治疗组，CD8＋细胞百分比低于常规治疗组，差异均有统计学意义（ P＜0．05）；而与健康对照组比较，血清锌、IgA、IgM、IgG水平仍较低，差异均有统计学意义（P＜0．05）。常规治疗组治疗后血清锌、IgA、IgM、IgG水平及CD3＋、CD4＋细胞百分比、CD4＋／CD8＋细胞比值仍低于健康对照组，CD8＋细胞百分比仍高于健康对照组，差异均有统计学意义（ P＜0．05）。结论锌可以有效地改善婴幼儿肺炎患儿的免疫功能，有利于缩短患儿的治疗时间，减少不良结局的发生。
목적：분석자대영유인폐염환인면역공능적영향。방법선취2014년5～7월수치적영유인폐염환인96례수궤분성자보조치료조화상규치료조，각48례。상규치료조급여상규치료조시，자보조치료조재상규치료적동시급여자제제。분별재치료전、치료후대량조각진행일차혈청자수평화면역공능검측。령선취동기체검건강영유인40례작위건강대조조。대3조적혈청자수평급면역공능진행통계분석。결과치료전량조환인혈청자、IgA、IgM、IgG수평급CD3＋、CD4＋세포백분비、CD4＋／CD8＋세포비치균저우건강대조조，CD8＋세포백분비균고우건강대조조，차이균유통계학의의（ P＜0．05）；단량조환인각지표비교차이균무통계학의의（P＞0．05）。자보조치료조치료후혈청자、IgA、IgM、IgG수평급CD3＋、CD4＋세포백분비、CD4＋／CD8＋세포비치균고우상규치료조，CD8＋세포백분비저우상규치료조，차이균유통계학의의（ P＜0．05）；이여건강대조조비교，혈청자、IgA、IgM、IgG수평잉교저，차이균유통계학의의（P＜0．05）。상규치료조치료후혈청자、IgA、IgM、IgG수평급CD3＋、CD4＋세포백분비、CD4＋／CD8＋세포비치잉저우건강대조조，CD8＋세포백분비잉고우건강대조조，차이균유통계학의의（ P＜0．05）。결론자가이유효지개선영유인폐염환인적면역공능，유리우축단환인적치료시간，감소불량결국적발생。
Objective To analyse effects of zinc on immune function in children with infantile pneumonia .Methods A total of 96 children with infantile pneumonia selected from May to July 2014 were randomly divided into zinc supplementary treatment group and routine treatment group ,with 48 cases in each group .Routine treatment group was given conventional treatment ,while the zinc supplementary treatment group was received conventional treatment combined with zinc supplement .The serum level of zinc and immune function were detected before and after treatment ,respectively .Other 40 healthy infants received physical examination were contemporarily selected as healthy control group .Results Before treatment ,the levels of serum zinc ,IgA ,IgM and IgG ,percentages of CD3+ ,CD4+ cells and the CD4+ /CD8+ ratio in the two groups of children with infantile pneumonia were lower than those in the healthy control group ,while percentage of CD8+ cells was lower than that in the healthy control group ,had statistically significant differences(P<0 .05) .While no statistically significant differences of indicators mentioned above were found between the zinc sup‐plementary treatment group and routine treatment group before treatment(P> 0 .05) .After treatment ,the levels of serum zinc , IgA ,IgM and IgG ,percentages of CD3+ ,CD4+ cells and the CD4+ /CD8+ ratio in the zinc supplementary treatment group were higher than those in the routine treatment group ,and percentage of CD8+ cells was lower than that in the routine treatment group , had statistically significant differences(P<0 .05);while compared with the healthy control group ,levels of serum zinc ,IgA ,IgM , IgG were still lower ,had statistically significant differences(P<0 .05) .After treatment ,levels of serum zinc ,IgA ,IgM ,IgG ,per‐centages of CD3+ ,CD4+ cells and the CD4+ /CD8+ ratio in the routine treatment group were still lower than those in the healthy control group ,and percentage of CD8+ cells was still higher than that in the healthy control group ,had statistically significant differences(P<0 .05) .Conclusion Zinc can effectively improve the immune function of children with infantile pneumonia ,which might shorten treatment time and reduce adverse outcomes .