国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
International Medicine and Health Guidance News
2015年
18期
2712-2714
,共3页
晚期肺癌%N-端脑利钠肽前体%心力衰竭%心功能分级
晚期肺癌%N-耑腦利鈉肽前體%心力衰竭%心功能分級
만기폐암%N-단뇌리납태전체%심력쇠갈%심공능분급
Advanced lung cancer%N-terminal pro-brain natriuretic peptide%Heart failure%Cardiac functional grading
目的 探讨晚期肺癌患者血浆N-端脑利钠肽前体(NT-proBNP)水平变化及其临床意义.方法 选取40例晚期肺癌患者为观察组,另选同期住院28例早期肺癌患者为对照组.分别评定观察组和对照组入院第2天和第9天的心功能分级,检测两组患者血浆NT-proBNP水平、左室射血分数(LVEF),并比较2个时间点各指标的差异.结果 入院第2天观察组患者心功能分级与对照组比较差异无统计学意义(P＞ 0.05);入院第9天观察组心功能衰竭发生率为15.0％(6/40),与对照组相比差异有统计学意义(P＜ 0.05).入院第2天、第9天观察组NT-proBNP与对照组比较均有统计学差异(P＜0.01),观察组入院第9天NT-proBNP与第2天比较有统计学差异(P＜ 0.01).结论 在患者心功能分级并未出现差异的情况下,观察组血浆NT-proBNP水平已明显升高,血浆NT-proBNP水平变化可以为患者心力衰竭并发症早期诊断和治疗提供依据,具有重要的临床应用价值.
目的 探討晚期肺癌患者血漿N-耑腦利鈉肽前體(NT-proBNP)水平變化及其臨床意義.方法 選取40例晚期肺癌患者為觀察組,另選同期住院28例早期肺癌患者為對照組.分彆評定觀察組和對照組入院第2天和第9天的心功能分級,檢測兩組患者血漿NT-proBNP水平、左室射血分數(LVEF),併比較2箇時間點各指標的差異.結果 入院第2天觀察組患者心功能分級與對照組比較差異無統計學意義(P＞ 0.05);入院第9天觀察組心功能衰竭髮生率為15.0％(6/40),與對照組相比差異有統計學意義(P＜ 0.05).入院第2天、第9天觀察組NT-proBNP與對照組比較均有統計學差異(P＜0.01),觀察組入院第9天NT-proBNP與第2天比較有統計學差異(P＜ 0.01).結論 在患者心功能分級併未齣現差異的情況下,觀察組血漿NT-proBNP水平已明顯升高,血漿NT-proBNP水平變化可以為患者心力衰竭併髮癥早期診斷和治療提供依據,具有重要的臨床應用價值.
목적 탐토만기폐암환자혈장N-단뇌리납태전체(NT-proBNP)수평변화급기림상의의.방법 선취40례만기폐암환자위관찰조,령선동기주원28례조기폐암환자위대조조.분별평정관찰조화대조조입원제2천화제9천적심공능분급,검측량조환자혈장NT-proBNP수평、좌실사혈분수(LVEF),병비교2개시간점각지표적차이.결과 입원제2천관찰조환자심공능분급여대조조비교차이무통계학의의(P＞ 0.05);입원제9천관찰조심공능쇠갈발생솔위15.0％(6/40),여대조조상비차이유통계학의의(P＜ 0.05).입원제2천、제9천관찰조NT-proBNP여대조조비교균유통계학차이(P＜0.01),관찰조입원제9천NT-proBNP여제2천비교유통계학차이(P＜ 0.01).결론 재환자심공능분급병미출현차이적정황하,관찰조혈장NT-proBNP수평이명현승고,혈장NT-proBNP수평변화가이위환자심력쇠갈병발증조기진단화치료제공의거,구유중요적림상응용개치.
Objective To explore the change of the level of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) in advanced lung cancer patients and its clinical significance.Methods 40 cases of advanced lung cancer were selected as observation group,and 28 cases of early lung cancer were selected as control group.At the 2nd,9th day after hospitalization,assessed cardiac functional grading,tested the level of plasma NT-proBNP and LVEF,and compared the differences of above indexes at different time points.Results There was no statistically significant difference in cardiac functional grading between two groups at the 2nd day after hospitalization (P＞0.05);at the 9th day after hospitalization,the incidence of heart failure in observation group was 15.0％(6/40),significantly higher than that in control group (P＜0.05).There were statistically significant differences in the level of NT-proBNP between two groups at the 2nd,9th day after hospitalization (P＜0.05).The level of NT-proBNP in observation group at the 9th day after hospitalization was significantly higher than that at the 2nd day after hospitalization (P＜0.01).Conclusion NT-proBNP is very sensitive in predicting cardiac complications of advanced lung cancer,and we should attach importance to its clinical significance.
