CAJ | 학술논문

蛋白质解旋包括高级结构的改变、二硫键的形成及断裂等；蛋白质的解旋广泛参与生物体内多种生理和病理过程，其中高级结构的改变对构象性疾病的发生、发展有重要影响。本文综述蛋白质解旋对构象性疾病的影响，并以白内障及阿尔兹海默症为例，探寻此类疾病共有的某些发病机制及相应的干预途径。
단백질해선포괄고급결구적개변、이류건적형성급단렬등；단백질적해선엄범삼여생물체내다충생리화병리과정，기중고급결구적개변대구상성질병적발생、발전유중요영향。본문종술단백질해선대구상성질병적영향，병이백내장급아이자해묵증위례，탐심차류질병공유적모사발병궤제급상응적간예도경。
Protein unwinding includes advanced structure changes, the formation and fracture of disulfide bond and so on. Protein unwinding is widely involved in the physiological and pathological processes in vivo, of which advanced structure changes have important influences on the occurrence and development of conformational diseases. In order to seek for the common pathological mechanism and corresponding intervention approach, this review summarizes the current information about conformational diseases, especially about cataract and Alzheimer's disease.