CAJ | 학술논문

目的：回顾性分析828个周期宫腔内人工授精授精时机及授精当日男方精液对妊娠结局的影响。方法将828例患者根据授精时机分为排卵前授精组及排卵后授精组，根据授精当日男方前向运动精子数分为<10×106组、(10~20)×106组、(20~30)×106组、(30~40)×106及>40×106组。分析比较不同组的女方年龄年龄、男方年龄、不孕年限、体质量指数(BMI)、刺激周期比率、妊娠率、流产率。结果排卵前授精组 BMI 及刺激周期比率高于排卵后组，差异有统计学意义(P <0.05)，女方年龄、男方年龄、不孕年限、前向运动精子≥10×106比率、妊娠率、流产率比较差异未见统计学意义(P >0.05)。不同精液浓度组女方年龄、不孕年限、BMI、刺激周期比率、妊娠率、流产率比较差异未见统计学意义(P >0.05)；>40×106组男方年龄低于其他四组，差异有统计学意义(P <0.05)。结论排卵前及排卵后进行人工授精结局比较差异未见统计学意义；授精当日精液浓度<10×106也有妊娠概率，精液浓度>10×106妊娠率不随精液浓度增加而增加；精液浓度>10×106若女方原因为主要不孕因素时流产率相应增加。
목적：회고성분석828개주기궁강내인공수정수정시궤급수정당일남방정액대임신결국적영향。방법장828례환자근거수정시궤분위배란전수정조급배란후수정조，근거수정당일남방전향운동정자수분위<10×106조、(10~20)×106조、(20~30)×106조、(30~40)×106급>40×106조。분석비교불동조적녀방년령년령、남방년령、불잉년한、체질량지수(BMI)、자격주기비솔、임신솔、유산솔。결과배란전수정조 BMI 급자격주기비솔고우배란후조，차이유통계학의의(P <0.05)，녀방년령、남방년령、불잉년한、전향운동정자≥10×106비솔、임신솔、유산솔비교차이미견통계학의의(P >0.05)。불동정액농도조녀방년령、불잉년한、BMI、자격주기비솔、임신솔、유산솔비교차이미견통계학의의(P >0.05)；>40×106조남방년령저우기타사조，차이유통계학의의(P <0.05)。결론배란전급배란후진행인공수정결국비교차이미견통계학의의；수정당일정액농도<10×106야유임신개솔，정액농도>10×106임신솔불수정액농도증가이증가；정액농도>10×106약녀방원인위주요불잉인소시유산솔상응증가。
Objective To retrospectively analyze the effect of 828 cycles intrauterine insemination fertilization time and the male semen quality on fertilization day on pregnancy outcome. Methods Eighty hundred and twenty-eight patients were divided into ovulation fertilization before group and after ovulation fertilization group according to the fertilization time, according to the man forward movement sperm count on the fertilization day, they were divided into < 10 × 106 group, (10 - 20) × 106 group, (20 - 30) × 106 group, (30 - 40) × 106 and > 40 × 106 group. The maternal age, paternal age, infertility, age, BMI, stimulate the cycle rate, pregnancy rate, miscarriage rate in different groups were analyzed and com-pared. Results BMI and stimulation cycle ratio in before ovulation fertilization group were higher than that in the after o-vulation group, the difference was significant (P < 0. 05), fixed number of year of the woman’s age, paternal age, infertil-ity, forward movement sperm 10 or more × 106 rate, pregnancy rate, miscarriage rate had no significant statistical differ-ence. In different sperm concentration groups, her age, infertility, age, BMI, stimulate the cycle rate, pregnancy rate, miscarriage rate had no significant difference (P > 0. 05). The paternal age in > 40 × 106 group was lower than the other four groups, the differences were significant (P < 0. 05). Conclusions The artificial insemination outcome without obvi-ous difference ovulation before and after ovulation, fertilization on sperm concentration < 10 × 106 have chances of pregnan-cy and the pregnancy rate of sperm concentration > 10 × 106 does not increase with the increase of sperm concentration;When sperm concentration > 10 × 106 ,if the woman cause miscarriage rate increase as the main factor infertility.