CAJ | 학술논문

目的：探讨脂蛋白( a)、同型半胱氨酸( HCY)、超敏C-反应蛋白( hs-CRP)三指标在冠心病中的应用和临床价值。方法将284名冠心病患者按照临床类型不同分为稳定型心绞痛( SAP)组、不稳定型心绞痛( UAP)组和心肌梗死( AMI)组，并以209例健康体检者作为健康对照组，采用免疫比浊法对冠心病各组和健康对照组的血清脂蛋白( a)、HCY、hs-CRP浓度进行检测，对所得计量资料进行统计学分析。对冠心病各分组中血清脂蛋白(LP)(a)、HCY、hs-CRP单个指标及三指标联合检测阳性率进行统计分析。结果冠心病各组血清LP(a)、HCY、hs-CRP浓度均值显著高于健康对照组，差异有统计学意义(P<0.05)。冠心病各组中该三项指标联合检测阳性率明显高于单一指标的检测，差异有统计学意义(P<0.05)。结论血清LP(a)、HCY、hs-CRP与冠心病的发生、发展密切相关，三者联合检测有利于冠心病的早发现、早诊断，早干预。三指标在冠心病的预防、风险评估、辅助诊断、及预后中有重要临床意义。
목적：탐토지단백( a)、동형반광안산( HCY)、초민C-반응단백( hs-CRP)삼지표재관심병중적응용화림상개치。방법장284명관심병환자안조림상류형불동분위은정형심교통( SAP)조、불은정형심교통( UAP)조화심기경사( AMI)조，병이209례건강체검자작위건강대조조，채용면역비탁법대관심병각조화건강대조조적혈청지단백( a)、HCY、hs-CRP농도진행검측，대소득계량자료진행통계학분석。대관심병각분조중혈청지단백(LP)(a)、HCY、hs-CRP단개지표급삼지표연합검측양성솔진행통계분석。결과관심병각조혈청LP(a)、HCY、hs-CRP농도균치현저고우건강대조조，차이유통계학의의(P<0.05)。관심병각조중해삼항지표연합검측양성솔명현고우단일지표적검측，차이유통계학의의(P<0.05)。결론혈청LP(a)、HCY、hs-CRP여관심병적발생、발전밀절상관，삼자연합검측유리우관심병적조발현、조진단，조간예。삼지표재관심병적예방、풍험평고、보조진단、급예후중유중요림상의의。
Objective To investigate the application and clinical value of lipoprotein ( a) , homocysteine ( HCY) and hypersensitive c-reactive protein ( hsCRP ) in coronary heart disease ( CHD ) . Methods According to the different clinical types, two hundrad and eighty-four patients with coronary heart disease ( CHD) were divided into three groups ( stable angina pectoris group, unstable angina pectoris group and myocardial infarction group) , and 209 cases of healthy people as the control group. The serum concentration levels of lipoprotein ( a) , HCY and hsCRP in each group were detec-ted through immunoturbidimetric assay. Results The concentration levels of lipoprotein (a), HCY and hsCRP in each CHD group were significantly higher than those in control group (P<0. 05). Meanwhile, the three factors combined detec-tion in coronary heart disease CHD group were significantly higher than that of single factor (P<0. 05). Conclusions Se-rum LP ( a) , HCY, HsCRP is closely correlated with the occurrence and development of coronary heart disease ( CHD) , and combined detection is helpful for the early detection, diagnosis and intervention of CHD. The three factors have impor-tant clinical value in prevention, risk assessment, and auxiliary diagnosis, and prognosis of CHD.