现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
Journal of Modern Laboratory Medicine
2015年
4期
122-124
,共3页
王妍%黄钦贤%林章礼%郭少君
王妍%黃欽賢%林章禮%郭少君
왕연%황흠현%림장례%곽소군
人乳头瘤病毒%宫颈癌%基因分型%宫颈脱落细胞
人乳頭瘤病毒%宮頸癌%基因分型%宮頸脫落細胞
인유두류병독%궁경암%기인분형%궁경탈락세포
human papillomavirus%cervical cancer%genotyping%cervical exfoliated cells
目的回顾过去一年汕头地区女性人群的人乳头瘤病毒(human papillomavirus,HPV)的感染状况。方法收集2013~2014年某院妇科门诊就诊的3664例女性患者的宫颈脱落细胞,行 HPV 基因扩增及分型诊断,检测 HPV 各亚型的感染率;并按年龄分为五组,探讨各组间 HPV 的感染状况。结果 HPV 阳性标本805例(22%,805/3664),其中单一感染和多重感染均可见。单一型较常见分别为16,52,43,58和56型;双重感染较常见分别为16+52,16+33和43+52型。经统计,各年龄组间 HPV 感染率差异有统计学显著性意义(χ2=27.08,P <0.01),以第一组(>25岁)、第二组(25~34岁)和第五组(<55岁)为 HPV 感染的高发组。结论汕头地区女性 HPV 感染以16,52,43,58和56型多见,且<35岁及>55岁为该地区 HPV 感染的高发人群。研制针对以上型别的疫苗有利于减少该地女性 HPV 的感染率和预防宫颈癌的发生。
目的迴顧過去一年汕頭地區女性人群的人乳頭瘤病毒(human papillomavirus,HPV)的感染狀況。方法收集2013~2014年某院婦科門診就診的3664例女性患者的宮頸脫落細胞,行 HPV 基因擴增及分型診斷,檢測 HPV 各亞型的感染率;併按年齡分為五組,探討各組間 HPV 的感染狀況。結果 HPV 暘性標本805例(22%,805/3664),其中單一感染和多重感染均可見。單一型較常見分彆為16,52,43,58和56型;雙重感染較常見分彆為16+52,16+33和43+52型。經統計,各年齡組間 HPV 感染率差異有統計學顯著性意義(χ2=27.08,P <0.01),以第一組(>25歲)、第二組(25~34歲)和第五組(<55歲)為 HPV 感染的高髮組。結論汕頭地區女性 HPV 感染以16,52,43,58和56型多見,且<35歲及>55歲為該地區 HPV 感染的高髮人群。研製針對以上型彆的疫苗有利于減少該地女性 HPV 的感染率和預防宮頸癌的髮生。
목적회고과거일년산두지구녀성인군적인유두류병독(human papillomavirus,HPV)적감염상황。방법수집2013~2014년모원부과문진취진적3664례녀성환자적궁경탈락세포,행 HPV 기인확증급분형진단,검측 HPV 각아형적감염솔;병안년령분위오조,탐토각조간 HPV 적감염상황。결과 HPV 양성표본805례(22%,805/3664),기중단일감염화다중감염균가견。단일형교상견분별위16,52,43,58화56형;쌍중감염교상견분별위16+52,16+33화43+52형。경통계,각년령조간 HPV 감염솔차이유통계학현저성의의(χ2=27.08,P <0.01),이제일조(>25세)、제이조(25~34세)화제오조(<55세)위 HPV 감염적고발조。결론산두지구녀성 HPV 감염이16,52,43,58화56형다견,차<35세급>55세위해지구 HPV 감염적고발인군。연제침대이상형별적역묘유리우감소해지녀성 HPV 적감염솔화예방궁경암적발생。
Objective To review the HPV infection status of the females in Shantou in the past years.Methods 3 664 speci-mens of cervical exfoliated cells of the female patients with gynecological disease from 2013 to 2014 were selected to ampli-fied HPV gene and conducted genetypes detection.The infection rate and various subtypes of HPV were analyzed.All these patients were divided into 5 groups according to their ages and the infection status of each group were also discussed.Results 805 patients were infected with HPV (22%,805/3 664).The single infection type and the mixed infection type were both visible,HPV-16 was the most common single infection type,followed by subtypes HPV-52,43,58 and 56.HPV16+52 was the most common mixed infection type,followed by HPV16+33 and HPV43+52.The infection rates of the each group were differences (χ2 =27.08,P < 0.01),No.1 (> 25),No.2 (25 ~ 34)and No.5 group (< 55)were the high-risk groups of HPV infection.Conclusion The main genotypes of these women whose infection with HPV were HPV-16,52,43,58 and 56 in Shantou region,respectively.The females aged less than 35 years old and more than 55 years old both had high-risk for HPV infection.It has important significance to developed the vaccines which can efficiently prevent HPV-16,52,43,58,56 and reduce the cervical cancer incidence.