CAJ | 학술논문

微小 RNA（miRNAs）是一种非编码的内源性 RNA 分子，miRNAs 的异常表达与疾病，尤其与恶性肿瘤的发生、发展存在密切的关系。研究证明，miRNAs 可以作为结直肠癌（colorectal cancer，CRC）早期诊断、治疗、预后的新的分子生物学标志物，同时，miRNAs 可作为体内 CRC 治疗的靶点。该文旨在对与 CRC 相关的 miRNAs 的表达、功能、作用机制、靶基因等及其在临床应用前景等方面作一综述。
미소 RNA（miRNAs）시일충비편마적내원성 RNA 분자，miRNAs 적이상표체여질병，우기여악성종류적발생、발전존재밀절적관계。연구증명，miRNAs 가이작위결직장암（colorectal cancer，CRC）조기진단、치료、예후적신적분자생물학표지물，동시，miRNAs 가작위체내 CRC 치료적파점。해문지재대여 CRC 상관적 miRNAs 적표체、공능、작용궤제、파기인등급기재림상응용전경등방면작일종술。
MicroRNAs (miRNAs)are small,non-coding RNAs that regulate the translation of specific protein coding genes. Recent studies have revealed the role of miRNAs in a variety of basic biological and pathological processes.Previous studies have suggested miRNAs can be servered as a new tumor biomarker in the early diagnosis,treatment and assessment of prog-nosis of CRC,which also can be servered as the treatment target in vivo of CRC patients.This paper reviews the expression and targets of miRNAs,its mechanism of the development and prospect in clinical application in CRC.