CAJ | 학술논문

目的比较高脂饲料喂养1个月的日本大耳兔和豚鼠的血脂变化及动脉粥样硬化形成情况。方法将12只兔和12只豚鼠分别采用数字表法随机分成两组，①兔对照组（ n＝6）：普通饲料喂养；②兔模型组（n＝6）：高脂饲料喂养；③豚鼠对照组（n＝6）：普通饲料喂养；④豚鼠模型组（n＝6）：高脂饲料喂养。0周及4周末酶法检测血脂；HE染色法观察主动脉弓病理变化。结果实验4周末兔模型组和豚鼠模型组血清低密度脂蛋白－胆固醇（ LDL-C）、总胆固醇（ TC）、高密度脂蛋白胆固醇（ HDL-C）均较对照组显著升高，差异均有统计学意义（P均＜0．05）；病理结果示：兔模型组83％（5／6）可见动脉粥样硬化早期病理改变，豚鼠模型组未见动脉粥样硬化病理改变。结论单纯高脂饲料喂养1月，兔可形成高脂血症和早期动脉粥样硬化，豚鼠只可形成高脂血症，兔较豚鼠快速形成动脉粥样硬化模型。
목적비교고지사료위양1개월적일본대이토화돈서적혈지변화급동맥죽양경화형성정황。방법장12지토화12지돈서분별채용수자표법수궤분성량조，①토대조조（ n＝6）：보통사료위양；②토모형조（n＝6）：고지사료위양；③돈서대조조（n＝6）：보통사료위양；④돈서모형조（n＝6）：고지사료위양。0주급4주말매법검측혈지；HE염색법관찰주동맥궁병리변화。결과실험4주말토모형조화돈서모형조혈청저밀도지단백－담고순（ LDL-C）、총담고순（ TC）、고밀도지단백담고순（ HDL-C）균교대조조현저승고，차이균유통계학의의（P균＜0．05）；병리결과시：토모형조83％（5／6）가견동맥죽양경화조기병리개변，돈서모형조미견동맥죽양경화병리개변。결론단순고지사료위양1월，토가형성고지혈증화조기동맥죽양경화，돈서지가형성고지혈증，토교돈서쾌속형성동맥죽양경화모형。
Objective To compare lipid changes and atherosclerosis of Japanese white rabbits and guinea pigs feed by high fat diet.Methods Twelve Japanese white rabbits and twelve guinea pigs were randomly divided in-to 2 groups respectively,1.Rabbit control group (n=6):chow diet;2.Rabbit model group (n=6):high fat diet;3. Guinea pig control group (n=6):chow diet;4.Guinea pig model group (n=6):high fat diet.Serum lipid were meas-ured by enzymatic at 0 week and 4weeks.Aorta pathological changes were observed by HE staining.Results The to-tal cholesterol, triglyceride, low density lipoprotein and high density lipoprotein of model groups were significantly higher than those in the control groups(P<0.05),and the difference was statistically significant.Pathology results showed that early stage pathological changes of atherosclerosis was founded in 83%(5/6) of rabbit model group,how-ever there was no atherosclerosis in guinea pig model group.Conclusion Simple fed high-fat diet for 1month,rabbits will have hyperlipidemia and early atherosclerosis,while guinea pigs only with hyperlipidemia.The model of athero-sclerosis could format repidly in rabbit compared with guinea pig.