CAJ | 학술논문

目的观察枳术党参颗粒的肠推进和镇吐作用. 方法采用阿托品、多巴胺以及肾上腺素诱导肠功能低下小鼠模型,研究枳术党参颗粒的肠推进作用;通过硫酸铜和顺铂诱导的家鸽呕吐模型,观察枳术党参颗粒的镇吐作用. 结果枳术党参颗粒20 g/kg 1次给药能提高由阿托品抑制的小鼠肠推进活动,枳术党参颗粒10、20 g/kg 3次预防给药能提高多巴胺和肾上腺素抑制的小鼠肠推进活动;枳术党参颗粒16 g/kg 1次给药能减少硫酸铜所致家鸽的呕吐次数,枳术党参颗粒(4、8、16 g/kg)3次给药对顺铂所致家鸽的呕吐无明显作用.结论枳术党参颗粒有明显的促进小鼠肠排空作用,对外周呕吐有一定的镇吐作用.
목적 관찰지술당삼과립적장추진화진토작용. 방법 채용아탁품、다파알이급신상선소유도장공능저하소서모형,연구지술당삼과립적장추진작용;통과류산동화순박유도적가합구토모형,관찰지술당삼과립적진토작용. 결과지술당삼과립20 g/kg 1차급약능제고유아탁품억제적소서장추진활동,지술당삼과립10、20 g/kg 3차예방급약능제고다파알화신상선소억제적소서장추진활동;지술당삼과립16 g/kg 1차급약능감소류산동소치가합적구토차수,지술당삼과립(4、8、16 g/kg)3차급약대순박소치가합적구토무명현작용.결론 지술당삼과립유명현적촉진소서장배공작용,대외주구토유일정적진토작용.
Objective To study the effects of zhizhu dangshen granules on intestinal propulsive function and an-temtic effect in animals. Methods The models of intestinal dysfunction induced by atropine, dopamine and epi-nephrine in mice were used to study gastrointestinal propulsive function. The models of vomit induced by copper sulfate and cisplatin in pigeon were used to study antemtic effect. Results A single administration of Zhizhu dang-shen granules (20 g/kg) could alleviate inhibition of intestinal propulsive function induced by atropine in mice. Three preventive administration of Zhizhu dangshen granules (10 g/kg and 20 g/kg) could improve the inhibition of intestinal propulsive function induced by dopamine and epinephrine in mice. A single administration of Zhizhu dangshen granules (16 g/kg) could reduce the vomitive times induced by copper sulfate in pigeon. Three preven-tive administration of Zhizhu dangshen granules (4 g/kg, 8 g/kg and 16 g/kg) had no effect on vomit induced by cisplatin in pigeon. Conclusion Zhizhu dangshen granules significantly increases intestinal propulsive function. It also has certain antiemetic effect on peripheral vomit.