现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
Journal of Modern Laboratory Medicine
2015年
4期
158-160
,共3页
杨丽%阎丽华%丁伟%蒋玉红
楊麗%閻麗華%丁偉%蔣玉紅
양려%염려화%정위%장옥홍
新生儿%溶血病%胆红素
新生兒%溶血病%膽紅素
신생인%용혈병%담홍소
newborn%hemolytic disease%bilirubin
目的：探讨新生儿 ABO 血型不合溶血病的临床与主要实验室特征。方法收集青岛市妇女儿童医院2013年6月～2015年2月收治的422例新生儿 ABO 溶血病病例，应用微柱凝胶技术并结合胆红素及网织红细胞指标对其进行系统分析。结果422例患儿中第一胎388例，其中 A 型为206例，B 型为216例，两者差异无统计学意义（χ2＝0.24，P ＞0.05）。男性218例，女性204例，两者差异无统计学意义（χ2＝0.46，P ＞0.05）。胆红素均以间接胆红素升高为主，总胆红素峰值在116～465μmol／L 之间，尤以256.5～342.0μmol／L 居多，占38.9％（χ2＝142.41，P ＜0.05）。162例患儿网织红细胞计数升高，占38.5％（χ2＝75.62，P ＜0.05）。溶血三项试验结果多为游离和放散试验同时阳性，占80.1％（χ2＝146.98，P ＜0.05）。结论新生儿 ABO 溶血病第一胎即可发病，溶血三项试验以游离和放散试验同时阳性居多。三项实验均阳性的患儿更易发生高胆红素血症。早发现、早治疗是防治该病，减少胆红素脑病的关键所在。
目的：探討新生兒 ABO 血型不閤溶血病的臨床與主要實驗室特徵。方法收集青島市婦女兒童醫院2013年6月～2015年2月收治的422例新生兒 ABO 溶血病病例，應用微柱凝膠技術併結閤膽紅素及網織紅細胞指標對其進行繫統分析。結果422例患兒中第一胎388例，其中 A 型為206例，B 型為216例，兩者差異無統計學意義（χ2＝0.24，P ＞0.05）。男性218例，女性204例，兩者差異無統計學意義（χ2＝0.46，P ＞0.05）。膽紅素均以間接膽紅素升高為主，總膽紅素峰值在116～465μmol／L 之間，尤以256.5～342.0μmol／L 居多，佔38.9％（χ2＝142.41，P ＜0.05）。162例患兒網織紅細胞計數升高，佔38.5％（χ2＝75.62，P ＜0.05）。溶血三項試驗結果多為遊離和放散試驗同時暘性，佔80.1％（χ2＝146.98，P ＜0.05）。結論新生兒 ABO 溶血病第一胎即可髮病，溶血三項試驗以遊離和放散試驗同時暘性居多。三項實驗均暘性的患兒更易髮生高膽紅素血癥。早髮現、早治療是防治該病，減少膽紅素腦病的關鍵所在。
목적：탐토신생인 ABO 혈형불합용혈병적림상여주요실험실특정。방법수집청도시부녀인동의원2013년6월～2015년2월수치적422례신생인 ABO 용혈병병례，응용미주응효기술병결합담홍소급망직홍세포지표대기진행계통분석。결과422례환인중제일태388례，기중 A 형위206례，B 형위216례，량자차이무통계학의의（χ2＝0.24，P ＞0.05）。남성218례，녀성204례，량자차이무통계학의의（χ2＝0.46，P ＞0.05）。담홍소균이간접담홍소승고위주，총담홍소봉치재116～465μmol／L 지간，우이256.5～342.0μmol／L 거다，점38.9％（χ2＝142.41，P ＜0.05）。162례환인망직홍세포계수승고，점38.5％（χ2＝75.62，P ＜0.05）。용혈삼항시험결과다위유리화방산시험동시양성，점80.1％（χ2＝146.98，P ＜0.05）。결론신생인 ABO 용혈병제일태즉가발병，용혈삼항시험이유리화방산시험동시양성거다。삼항실험균양성적환인경역발생고담홍소혈증。조발현、조치료시방치해병，감소담홍소뇌병적관건소재。
Objective To investigate the clinical and laboratory feature of neonatal hemolytic disease (HDN)occurred in Qingdao caused by mother-baby ABO blood type disagreement.Methods Serum bilirubin (TBIL)test and micro column gel technology were used on 422 cases neonatal hemolytic disease children blood samples (collected from Jun.2013 to Feb.2015).Results There were 388 cases first-born children among 422 cases including 206 cases of type A and 216 of type B and the difference between them was not statistically significant (χ2 =0.24,P >0.05).The difference between male (218 cases)and female (204 cases)was not statistically significant (χ2 =0.24,P >0.05)too.The indirect bilirubin (IBI)increas-ing was more obviously.The peak level of serum bilirubin was 116~465 μmol/L and 256.5~342.0 μmol/L was 38.9% (χ2=0.24,P >0.05).162 cases reticulocyte count was increased nearly 38.5% (χ2 =75.62,P <0.05).RBC antibody release test and serum free antibody test were often positive and the percentage was 80.1% (χ2 =146.98,P <0.05).Conclusion The neonatal hemolytic disease may turn up in first-born children.The child with three positive test was more sensitive to neonatal hyperbilirubinemia.RBC antibody release test and serum free antibody test are often positive.It is important to make the early diagnosis and treatment as soon as possible for reducing the bilirubin encephalopathy.
