CAJ | 학술논문

目的：观察不同剂量柴芪汤对代谢综合征模型大鼠糖脂代谢及胰岛素抵抗（ IR）的影响。方法56只大鼠分为正常组16只，模型组16只，柴芪汤低、中、高剂量组各8只。采用高脂高糖高盐饲料持续喂养方式复制大鼠代谢综合征模型。柴芪汤各组从第9周开始分别灌胃给予不同剂量：低剂量组为1．90 g／（kg· d），中剂量组5．71 g／（kg· d），高剂量组17．13 g／（kg· d）。实验第8周末，模型组与正常组随机选取8只大鼠采血，实验第12周末，各组大鼠均行腹主动脉采血。用生化法检测血脂（ TG、TC、HDL-C、LDL-C）、空腹血糖（ FBG），放免法检测空腹胰岛素（ FINS），公式计算胰岛素抵抗指数（ IRI）。结果治疗4周后，与模型组比较，柴芪汤低剂量组FINS、TG明显下降（P＜0．05），HDL-C明显升高（P＜0．05）；高、中剂量组FINS、TG、TC、IRI明显下降（P＜0.05）， HDL-C明显升高（P＜0．05）。结论柴芪汤可改善代谢综合征大鼠糖脂代谢，并能减轻IR，以中、高剂量效果明显。
목적：관찰불동제량시기탕대대사종합정모형대서당지대사급이도소저항（ IR）적영향。방법56지대서분위정상조16지，모형조16지，시기탕저、중、고제량조각8지。채용고지고당고염사료지속위양방식복제대서대사종합정모형。시기탕각조종제9주개시분별관위급여불동제량：저제량조위1．90 g／（kg· d），중제량조5．71 g／（kg· d），고제량조17．13 g／（kg· d）。실험제8주말，모형조여정상조수궤선취8지대서채혈，실험제12주말，각조대서균행복주동맥채혈。용생화법검측혈지（ TG、TC、HDL-C、LDL-C）、공복혈당（ FBG），방면법검측공복이도소（ FINS），공식계산이도소저항지수（ IRI）。결과치료4주후，여모형조비교，시기탕저제량조FINS、TG명현하강（P＜0．05），HDL-C명현승고（P＜0．05）；고、중제량조FINS、TG、TC、IRI명현하강（P＜0.05）， HDL-C명현승고（P＜0．05）。결론시기탕가개선대사종합정대서당지대사，병능감경IR，이중、고제량효과명현。
Objective To study the effects of Chaiqi decoction ( CQD) at different doses on glucose and lipid metabolism and insulin resistance( IR) in metabolic syndrome ( MS) rat model.Methods The MS rat model was induced by feeding diet of high fat, high sugar and high salt.Altogether 56 male rats were randomly divided into normal group ( n =16 ) , model group ( n =16 ) , CQD low dose group ( low-dose group, n=8), CQD middle dose group(mid-dose group, n=8) and CQD high dose group(high-dose group, n=8) .The low-, mid-, and high-groups were taken CQD by intragastric administration at dose of 1.90, 5.71 and 17.13 g/kg daily for four weeks.At the end of the 8th week, eight rats of normal group and model group were sacrificed, and at the end of the 12th week, all the rats in each group were sacrificed.Serum TG, TC, HDL-C, LDL-C, fasting blood glucose ( FBG) and fasting insulin ( FINS) were detected, while insulin resistance index ( IRI) was calculated.Results After taking CQD for four weeks , compared with model group, FINS and TG in low-dose group decreased significantly (P<0.05) while HDL-C increased significantly ( P <0.05); FINS, TG, TC, IRI decreased significantly while HDL-C increased significantly in both mid-and high-dose groups (P<0.05).Conclusion CQD would attenuate the lipid metabolism of rats with metabolic syndrome and reduce IR.Furthermore, the mid-dose group and high-dose group got better effects than those of low-dose group.