CAJ | 학술논문

介孔SiO2纳米微球(MSNs)具有良好的理化性能，在疾病诊治方面具有广阔的应用前景，但若要成功应用于人体，需要完善其生物相容性研究。 MSNs对于细胞的毒性与 MSNs 能否被摄取进入细胞，以及进入细胞的量有关，并取决于细胞的类型和MSNs本身的性状。通过一系列物理和化学方法的改进，可以明显改善 MSNs 的血液相容性，降低溶血作用。介孔Si O 2纳米微球经静脉注射后分布于动物的肝脏、脾脏、肾脏、心脏、肠胃、肌肉和肺脏，其毒性作用与浓度有关；MSNs 作为一种异物进入体内后可能会诱发机体产生一定程度的超敏反应。介孔 Si O 2纳米微球具有较好的生物相容性，但其采用何种方式应用仍需进一步研究。
개공SiO2납미미구(MSNs)구유량호적이화성능，재질병진치방면구유엄활적응용전경，단약요성공응용우인체，수요완선기생물상용성연구。 MSNs대우세포적독성여 MSNs 능부피섭취진입세포，이급진입세포적량유관，병취결우세포적류형화MSNs본신적성상。통과일계렬물리화화학방법적개진，가이명현개선 MSNs 적혈액상용성，강저용혈작용。개공Si O 2납미미구경정맥주사후분포우동물적간장、비장、신장、심장、장위、기육화폐장，기독성작용여농도유관；MSNs 작위일충이물진입체내후가능회유발궤체산생일정정도적초민반응。개공 Si O 2납미미구구유교호적생물상용성，단기채용하충방식응용잉수진일보연구。
Because of the good physical and chemical properties of mesoporous silica nanoparticles (MSNs), MSNs Have broad prospect of application in disease diagnosis and treatment,but before it can be successfully applied in the human body,the biocompatibility of it must be improved.The cytotoxicity of MSNs was related to the way and quantity it can be uptaken into the cells.Those depend on the cell type and character of the MSNs. By improvement of physical and chemical methods,the biocompatibility of mesoporous silica nanoparticles can be obviously improved,and its hemolysis can be reduced too.MSNs distribute mainly in the liver,spleen,lungs, kidney,intestines,stomach,muscle and heart.The toxicity depend on the concentration.As a foreign matter,a certain extent hypersensitivity can be induced when the MSNs enter into the body (in vivo),MSNs exhibit good biocompatibility in vitro and in vivo,but the way to be adopted needs further study.