现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
Journal of Modern Laboratory Medicine
2015年
4期
50-52
,共3页
慢性肝炎%前清蛋白%总胆汁酸%肝穿刺活检
慢性肝炎%前清蛋白%總膽汁痠%肝穿刺活檢
만성간염%전청단백%총담즙산%간천자활검
chronic hepatitis%PA%TBA%liver biopsy
目的:探讨联合检测前清蛋白(prealbumin,PA)、总胆汁酸(total bile acid,TBA)与肝穿刺活检,在慢性肝炎中的临床价值。方法收集延安大学附属医院2013年10月~2014年3月期间的慢性肝炎住院患者172例为慢性肝炎组,同期正常健康体检者45例为对照组。两组分别行 PA 和 TBA 检测,PA 采用免疫比浊法,TBA 采用循环酶法,慢性肝炎组同时行经皮穿刺肝组织学检测。结果慢性肝炎组 PA 值(179.12±8.46 mg/L)低于对照组(257.34±6.38 mg/L),差异具有统计学意义(P <0.05);慢性肝炎组 TBA 值(30.58±9.37μmol/L)高于对照组(8.16±1.59μmol/L),差异具有统计学意义(P <0.05);PA 含量与病理分级呈负相关(rs =-0.617,P <0.05),TBA 含量与病理分级呈正相关(rs =0.724,P <0.05);PA 单独检测诊断阳性率为58.7%(101/172),TBA 单独检测诊断阳性率为80.2%(138/172)。两者联合检测诊断阳性率为93.6%(161/172),高于单独测定,差异具有统计学意义(P <0.05)。结论血清 PA 和 TBA 水平测定除能反映肝功能减退及肝内炎症程度以外,二者联合检测更能提高慢性肝炎诊断的阳性率,与组织学检测相比具有方便、简单、易操作的优点。
目的:探討聯閤檢測前清蛋白(prealbumin,PA)、總膽汁痠(total bile acid,TBA)與肝穿刺活檢,在慢性肝炎中的臨床價值。方法收集延安大學附屬醫院2013年10月~2014年3月期間的慢性肝炎住院患者172例為慢性肝炎組,同期正常健康體檢者45例為對照組。兩組分彆行 PA 和 TBA 檢測,PA 採用免疫比濁法,TBA 採用循環酶法,慢性肝炎組同時行經皮穿刺肝組織學檢測。結果慢性肝炎組 PA 值(179.12±8.46 mg/L)低于對照組(257.34±6.38 mg/L),差異具有統計學意義(P <0.05);慢性肝炎組 TBA 值(30.58±9.37μmol/L)高于對照組(8.16±1.59μmol/L),差異具有統計學意義(P <0.05);PA 含量與病理分級呈負相關(rs =-0.617,P <0.05),TBA 含量與病理分級呈正相關(rs =0.724,P <0.05);PA 單獨檢測診斷暘性率為58.7%(101/172),TBA 單獨檢測診斷暘性率為80.2%(138/172)。兩者聯閤檢測診斷暘性率為93.6%(161/172),高于單獨測定,差異具有統計學意義(P <0.05)。結論血清 PA 和 TBA 水平測定除能反映肝功能減退及肝內炎癥程度以外,二者聯閤檢測更能提高慢性肝炎診斷的暘性率,與組織學檢測相比具有方便、簡單、易操作的優點。
목적:탐토연합검측전청단백(prealbumin,PA)、총담즙산(total bile acid,TBA)여간천자활검,재만성간염중적림상개치。방법수집연안대학부속의원2013년10월~2014년3월기간적만성간염주원환자172례위만성간염조,동기정상건강체검자45례위대조조。량조분별행 PA 화 TBA 검측,PA 채용면역비탁법,TBA 채용순배매법,만성간염조동시행경피천자간조직학검측。결과만성간염조 PA 치(179.12±8.46 mg/L)저우대조조(257.34±6.38 mg/L),차이구유통계학의의(P <0.05);만성간염조 TBA 치(30.58±9.37μmol/L)고우대조조(8.16±1.59μmol/L),차이구유통계학의의(P <0.05);PA 함량여병리분급정부상관(rs =-0.617,P <0.05),TBA 함량여병리분급정정상관(rs =0.724,P <0.05);PA 단독검측진단양성솔위58.7%(101/172),TBA 단독검측진단양성솔위80.2%(138/172)。량자연합검측진단양성솔위93.6%(161/172),고우단독측정,차이구유통계학의의(P <0.05)。결론혈청 PA 화 TBA 수평측정제능반영간공능감퇴급간내염증정도이외,이자연합검측경능제고만성간염진단적양성솔,여조직학검측상비구유방편、간단、역조작적우점。
Objective To investigate the clinical value of combined test of prealbumin (PA),total bile acid(TBA)and liver bi-opsy in chronic hepatitis.Methods 172 patients hospitalized with chronic hepatitis in the Affiliated Hospital of Yan’an Uni-versity Medical College from October,2013 to March,2014 was collected as the chronic hepatitis group;and 45 cases of nor-mal healthy control of the corresponding period was collected as the control group.Prealbumin,TBA was detected respec-tively in the two groups.Immunoturbidimetry was adopted in PA,Enzymatic cycling assay was employed in TBA,and at the same time percutaneous puncture of liver histology was detected in the chronic hepatitis group.Results The PA in the chro-nic hepatitis group (179.12±8.46 mg/L)was lower than the control group (257.34±6.38 mg/L),and the difference was statistically significant (P <0.05).The TBA in the chronic hepatitis group (30.58±9.37 μmol/L)was higher than the con-trol group (8.16±1.59 μmol/L)and also the difference was statistically significant (P <0.05).PA was negatively correla-ted with the pathological grades (rs =-0.617,P <0.05),and TBA was positively correlated with pathological grades (rs =0.724,P <0.05).The separate diagnostic positive rate of PA was 58.7% (101/172),while the TBA was 93.6% (161/172).The combined diagnostic positive rate of the two was 93.6% (161/172),it was higher than the separate rate and was statistically significant (P <0.05).Conclusion The serum levels of PA and TBA can reflect the extent and degree of hypo-hepatia and hepatic inflammation,and the combined detection of the two will be much sensitive to the diagnosis of chronic hepatitis,and compared with histological detection,it is convenient,simple,and easy to operate.