CAJ | 학술논문

目的：探讨膝关节滑膜炎滑膜清理术前后基质金属蛋白酶（MMP）-7与基质金属蛋白酶（MMP）-9测定和关节功能的影响。方法膝关节滑膜炎患者72例根据随机抽签方法分为治疗组与对照组各36例，对照组采用传统滑膜刨削手术治疗，治疗组采用关节镜下滑膜清理术。结果治疗后治疗组的有效率是97.2％，对照组的有效率是80.6％，治疗组比对照组的疗效更为显著，差异具有统计学意义（P ＜0.05）。两组术后的 Lysholm 功能评分明显增加，而疼痛评分明显减少，与术前对比差异明显，具有统计学意义（P ＜0.05）；同时术后治疗组的 Lysholm 功能评分与疼痛评分与对照组对比差异也有统计学意义（P ＜0.05）。术后两组滑膜组织的 MMP-7与 MMP-9阳性表达率都明显降低（P ＜0.05），与此同时，术后治疗比对照组在 MMP-7与 MMP-9阳性表达率方面要明显低，差异具有统计学意义（P ＜0.05）。结论关节镜下滑膜清理术治疗膝关节滑膜炎能缓解疼痛，改善膝关节功能，降低 MMP-7与 MMP-9的表达，从而提高治疗综合疗效。
목적：탐토슬관절활막염활막청리술전후기질금속단백매（MMP）-7여기질금속단백매（MMP）-9측정화관절공능적영향。방법슬관절활막염환자72례근거수궤추첨방법분위치료조여대조조각36례，대조조채용전통활막포삭수술치료，치료조채용관절경하활막청리술。결과치료후치료조적유효솔시97.2％，대조조적유효솔시80.6％，치료조비대조조적료효경위현저，차이구유통계학의의（P ＜0.05）。량조술후적 Lysholm 공능평분명현증가，이동통평분명현감소，여술전대비차이명현，구유통계학의의（P ＜0.05）；동시술후치료조적 Lysholm 공능평분여동통평분여대조조대비차이야유통계학의의（P ＜0.05）。술후량조활막조직적 MMP-7여 MMP-9양성표체솔도명현강저（P ＜0.05），여차동시，술후치료비대조조재 MMP-7여 MMP-9양성표체솔방면요명현저，차이구유통계학의의（P ＜0.05）。결론관절경하활막청리술치료슬관절활막염능완해동통，개선슬관절공능，강저 MMP-7여 MMP-9적표체，종이제고치료종합료효。
Objective To investigate effects analysis of joint function and MMP-7 and MMP-9 measurement after synovial ar-throscopic debridement for knee synovitis.Methods 72 patients with knee synovitis method based on a random draw were e-qually divided into the treatment group and the control group,the control group were given the traditional synovial planing surgery.The treatment group were given the arthroscopic debridement synovium.Results After treatment,the response rates in the treatment group and the control group were 97.2% and 80.6% respectively.The response rate of the treatment group were significantly better than the control group.The difference was statistically significant (P <0.05).The postopera-tive Lysholm scores were increased significantly,while the pain scores were significantly reduced,and the postoperative Ly-sholm score and pain scores difference compared between the two groups were also statistically significant.The difference was statistically significant (P <0.05).The postoperative synovial tissue MMP-7 and MMP-9 expression rates were in the two groups significantly lower.The difference was statistically significant (P <0.05),while the postoperative MMP-7 and MMP-9 expression rates of the treatment group were ignificantly lower than the control group (P <0.05).Conclusion Syn-ovial arthroscopic debridement for knee synovitis can relieve pain and improve knee function,reduce the expression of MMP-7 and MMP-9,thereby enhance the overall efficacy of the treatment.