CAJ | 학술논문

目的：研究肺癌患者在化疗前后的血清癌胚抗原（CEA）、铁蛋白（Ferritin）、血浆 D-二聚体（D-D）的水平变化，评估其对于判断肺癌患者化疗效果的应用价值。方法选择2011年9月～2014年9月确诊的120例肺癌患者，根据 WHO制定的实体瘤疗效评价标准进行疗效判定。另选120例健康体检者作为对照组，分别检测肺癌组和对照组的血清 CEA， Ferritin 和血浆 D-D 的含量，分析肺癌化疗前后及不同化疗疗效分期患者的结果变化规律。结果肺癌患者化疗前血清CEA，Ferritin 和血浆 D-D 的含量均明显高于化疗后和对照组，差异具有统计学意义（t＝4.123～14.224，P ＜0.05）；疗效为完全缓解（CR）期的肺癌患者血清 CEA，Ferritin 和血浆 D-D 含量低于部分缓解（PR）期、稳定（SD）期和进展（PD）期，差异具有统计学意义（t＝4.230～12.336，P ＜0.05）。结论检测肺癌患者化疗前后的血清 CEA，Ferritin 和血浆 D-D 等项目有一定的临床价值，其水平变化可以作为肺癌化疗疗效的参考指标。
목적：연구폐암환자재화료전후적혈청암배항원（CEA）、철단백（Ferritin）、혈장 D-이취체（D-D）적수평변화，평고기대우판단폐암환자화료효과적응용개치。방법선택2011년9월～2014년9월학진적120례폐암환자，근거 WHO제정적실체류료효평개표준진행료효판정。령선120례건강체검자작위대조조，분별검측폐암조화대조조적혈청 CEA， Ferritin 화혈장 D-D 적함량，분석폐암화료전후급불동화료료효분기환자적결과변화규률。결과폐암환자화료전혈청CEA，Ferritin 화혈장 D-D 적함량균명현고우화료후화대조조，차이구유통계학의의（t＝4.123～14.224，P ＜0.05）；료효위완전완해（CR）기적폐암환자혈청 CEA，Ferritin 화혈장 D-D 함량저우부분완해（PR）기、은정（SD）기화진전（PD）기，차이구유통계학의의（t＝4.230～12.336，P ＜0.05）。결론검측폐암환자화료전후적혈청 CEA，Ferritin 화혈장 D-D 등항목유일정적림상개치，기수평변화가이작위폐암화료료효적삼고지표。
Objective To investigate changes in the level of serum CEA,Ferritin and plasma D-D of the lung cancer patients suffering before and after the chemotherapy,and evaluate its application value in judging the curative effect of chemotherapy on the lung cancer patients.Methods Chose 120 lung cancer patients diagnosed from September 2011 to September 2014, and determined the curative effect in accordance with the standard for evaluating the curative effect of solid tumors set down by WHO.Chose another group of 120 healthy physical examinees as its control group.Tested the contents of serum CEA, Ferritin and plasma D-D of both groups respectively and analyzed the rules of change in the results of the patients before and after chemotherapy and in different chemotherapeutic effect stages.Results The contents of serum CEA,Ferritin and plas-ma D-D of the lung cancer patients were obviously higher than those of such patients after chemotherapy and those of the control group,and the difference was of statistical significance (t=4.123~14.224,P <0.05).The contents of serum CEA, Ferritin and plasma D-D of the patient at complete remission (CR)stage were lower than those at partial remission (PR) stage,stable disease (SD)stage and progress disease (PD)stage,and the difference was of statistical significance (t=4.230~12.336,P <0.05).Conclusion The test on the serum CEA,Ferritin and plasma D-D of the lung cancer patients before and after chemotherapy is of certain clinical value and the change in their content levels can be taken as a reference index for the chemotherapeutic effect of lung cancer patients.