CAJ | 학술논문

目的：探讨乙型肝炎病毒（HBV ）携带者外周血细胞因子γ干扰素（IFN‐γ）、白细胞介素‐32（IL‐32）和白细胞介素‐6（IL‐6）水平变化及其与肝功能水平和 HBV DNA载量的相关性。方法收集60例 HBV携带者空腹血清标本，其中慢性 HBV携带者39例，非活动性乙型肝炎表面抗原（HBsAg ）携带者21例，另收集体检健康者50例（对照组），检测血清IFN‐γ、IL‐32和IL‐6水平、HBV DNA载量及血清肝功能水平，并进行相关性分析。结果与对照组相比，慢性 HBV携带者和非活动性 HBsAg携带者外周血IFN‐γ、IL‐32和IL‐6水平均升高，差异均有统计学意义（P＜0．05）；中病毒载量慢性HBV携带者外周血IFN‐γ、IL‐32和IL‐6水平均高于低病毒载量与高病毒载量携带者，但差异均无统计学意义（ P＞0．05）；HBV携带者外周血IL‐32水平与AST水平呈正相关（r＝0．32，P＜0．05），与ALB水平呈负相关（r＝－0．27，P＜0．05）。结论细胞因子IFN‐γ、IL‐32和IL‐6在慢性HBV感染过程中可能起重要作用，可作为评估HBV携带者肝脏炎症严重程度的重要指标。
목적：탐토을형간염병독（HBV ）휴대자외주혈세포인자γ간우소（IFN‐γ）、백세포개소‐32（IL‐32）화백세포개소‐6（IL‐6）수평변화급기여간공능수평화 HBV DNA재량적상관성。방법수집60례 HBV휴대자공복혈청표본，기중만성 HBV휴대자39례，비활동성을형간염표면항원（HBsAg ）휴대자21례，령수집체검건강자50례（대조조），검측혈청IFN‐γ、IL‐32화IL‐6수평、HBV DNA재량급혈청간공능수평，병진행상관성분석。결과여대조조상비，만성 HBV휴대자화비활동성 HBsAg휴대자외주혈IFN‐γ、IL‐32화IL‐6수평균승고，차이균유통계학의의（P＜0．05）；중병독재량만성HBV휴대자외주혈IFN‐γ、IL‐32화IL‐6수평균고우저병독재량여고병독재량휴대자，단차이균무통계학의의（ P＞0．05）；HBV휴대자외주혈IL‐32수평여AST수평정정상관（r＝0．32，P＜0．05），여ALB수평정부상관（r＝－0．27，P＜0．05）。결론세포인자IFN‐γ、IL‐32화IL‐6재만성HBV감염과정중가능기중요작용，가작위평고HBV휴대자간장염증엄중정도적중요지표。
Objective To explore changes of levels of interferon‐γ(IFN‐γ) ,interleukin‐32(IL‐32) and interleukin‐6(IL‐6) in pe‐ripheral blood and the correlation between peripheral IFN‐γ,IL‐32 ,IL‐6 and liver function level and hepatitis B virus(HBV) DNA load in HBV carriers .Methods Sixty HBV carriers ,including 39 cases of chronic HBV carriers and 21 cases of inactive hepatitis B surface antigen(HBsAg) carriers ,and 50 healthy individuals were collected .Serum levels of IFN‐γ,IL‐32 and IL‐6 ,the amount of HBV DNA and liver function were detected ,and clinical correlations were analysed .Results Compared with the control group ,ser‐um levels of IFN‐γ,IL‐32 and IL‐6 of chronic HBV carriers and inactive HBsAg carriers were significantly increased (P<0 .05) . Compared with chronic HBV carriers with low amount of HBV DNA loads and high amount of HBV DNA loads ,chronic HBV car‐riers with medial HBV DNA loads had higher serum levels of IFN‐γ,IL‐32 and IL‐6 ,but no statistically significant differences were observed(P>0 .05) .There was positive correlation between IL‐32 level and ALT level (r=0 .32 ,P<0 .05) ,and negative correla‐tion between IL‐32 level and ALB level(r= -0 .27 ,P<0 .05) .Conclusion IFN‐γ,IL‐32 and IL‐6 may play important roles in chro‐nic HBV infection ,the levels of IFN‐γ,IL‐32 and IL‐6 could be used as important indicators to assess the severity of inflammation in HBV carriers .