国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
International Journal of Laboratory Medicine
2015年
18期
2620-2621,2624
,共3页
王甲甲%张娟%钟佳伶%黄文芳
王甲甲%張娟%鐘佳伶%黃文芳
왕갑갑%장연%종가령%황문방
原发性肝癌%甲胎蛋白%高尔基体糖蛋白73%肿瘤特异性生长因子
原髮性肝癌%甲胎蛋白%高爾基體糖蛋白73%腫瘤特異性生長因子
원발성간암%갑태단백%고이기체당단백73%종류특이성생장인자
primary liver cancer%alpha-fetoprotein%golgi glycoprotein 73%tumor specific grow th factor
目的：评价肿瘤标志物甲胎蛋白（AFP）、高尔基体糖蛋白73（GP73）、肿瘤特异性生长因子（TSGF）对原发性肝癌（PHC）的诊断价值及联合检测的意义。方法分别检测90例PHC患者（PHC组）、52例肝癌转移患者（肝癌转移）、41例良性肝病患者（良性肝病组）和55例体检健康者（健康对照组）血清AFP、GP73和TSGF水平，分析AFP、GP73、TSGF联合检测对PHC的诊断价值。结果 PHC组血清AFP、GP73、TSGF水平均高于良性肝病组及健康对照组，差异均有统计学意义（P＜0．05）。单独检测AFP、GP73和TSGF诊断PHC的特异度分别为79．7％、71．6％和83．1％，灵敏度分别为57．8％、74．4％、65．6％；三者联合检测可提高诊断PHC的灵敏度（96．6％），但特异度（68．9％）有所下降。联合检测AFP、GP73、TSGF可提高AFP阴性或低浓度PHC患者的早期诊断率。结论联合检测AFP、GP73和TSGF作为诊断PHC的重要指标，可显著提高PHC的早期诊断率。
目的：評價腫瘤標誌物甲胎蛋白（AFP）、高爾基體糖蛋白73（GP73）、腫瘤特異性生長因子（TSGF）對原髮性肝癌（PHC）的診斷價值及聯閤檢測的意義。方法分彆檢測90例PHC患者（PHC組）、52例肝癌轉移患者（肝癌轉移）、41例良性肝病患者（良性肝病組）和55例體檢健康者（健康對照組）血清AFP、GP73和TSGF水平，分析AFP、GP73、TSGF聯閤檢測對PHC的診斷價值。結果 PHC組血清AFP、GP73、TSGF水平均高于良性肝病組及健康對照組，差異均有統計學意義（P＜0．05）。單獨檢測AFP、GP73和TSGF診斷PHC的特異度分彆為79．7％、71．6％和83．1％，靈敏度分彆為57．8％、74．4％、65．6％；三者聯閤檢測可提高診斷PHC的靈敏度（96．6％），但特異度（68．9％）有所下降。聯閤檢測AFP、GP73、TSGF可提高AFP陰性或低濃度PHC患者的早期診斷率。結論聯閤檢測AFP、GP73和TSGF作為診斷PHC的重要指標，可顯著提高PHC的早期診斷率。
목적：평개종류표지물갑태단백（AFP）、고이기체당단백73（GP73）、종류특이성생장인자（TSGF）대원발성간암（PHC）적진단개치급연합검측적의의。방법분별검측90례PHC환자（PHC조）、52례간암전이환자（간암전이）、41례량성간병환자（량성간병조）화55례체검건강자（건강대조조）혈청AFP、GP73화TSGF수평，분석AFP、GP73、TSGF연합검측대PHC적진단개치。결과 PHC조혈청AFP、GP73、TSGF수평균고우량성간병조급건강대조조，차이균유통계학의의（P＜0．05）。단독검측AFP、GP73화TSGF진단PHC적특이도분별위79．7％、71．6％화83．1％，령민도분별위57．8％、74．4％、65．6％；삼자연합검측가제고진단PHC적령민도（96．6％），단특이도（68．9％）유소하강。연합검측AFP、GP73、TSGF가제고AFP음성혹저농도PHC환자적조기진단솔。결론연합검측AFP、GP73화TSGF작위진단PHC적중요지표，가현저제고PHC적조기진단솔。
Objective To evaluate the diagnostic value of three tumor markers ,including alpha‐fetoprotein(AFP) ,golgi glyco‐protein 73(GP73)and tumor specific growth factor(TSGF) ,and significance of combined detection in diagnosis of primary liver cancer(PHC) .Methods Serum levels of AFP ,GP73 and TSGF were detected in 90 cases of patients with PHC(PHC group) ,52 cases of patients with liver metastasis(liver metastasis group) ,41 cases of patients with benign liver disease(benign liver disease group) ,and 55 cases of healthy individuals(healthy control group) .And clinical value of combined detection of AFP ,GP73 and TS‐GF for diagnosing PHC was analysed .Results The serum levels of AFP ,GP73 and TSGF were significantly higher than those in benign liver disease group and healthy control group ,the differences were statistically significant(P< 0 .05) .The specificity of AFP ,GP73 and TSGF in diagnosis of PHC was 79 .7% ,71 .6% and 83 .1% ,respectively .The sensitivity of AFP ,GP73 and TSGF in the diagnosis of PHC was 57 .8% ,74 .4% and 65 .6% ,respectively .The combined detection of AFP ,GP73 and TSGF improved the sensitivity for diagnosing PHC(96 .6% ) ,while the specificity of combined detection was decreased(68 .9% ) .And the diagnosis rates of PHC patients with negative AFP or low levels of AFP were increased when combined the three tumor markers . Conclusion Combined detection of AFP ,GP73 and TSGF as a significant indicator for diagnosing PHC could improve the diagnosis rate of PHC .
