CAJ | 학술논문

目的：比较激光多点扫描与单点多次扫描治疗非增生期糖尿病视网膜病变的疗效。 　　方法：选取2010-01/2014-01期间我们收治的50例非增生期糖尿病视网膜病变患者为研究对象,采用随机数表法将50例患者分为观察组和对照组,观察组患者25例43眼,采用577 nm激光多点扫描一次完成全视网膜激光光凝( PRP)治疗,对照组患者25例41眼,采用单点多次扫描完成PRP治疗。对比两组患者不同时间的视野平均阈值敏感度、F-ERG a波振幅、F-ERG b波振幅,两组患者的临床有效率、激光能量、光斑数量、能量密度。 　　结果：两组患者治疗后1d的视野平均阈值敏感度均低于治疗前1d,差异具有统计学意义(t=2.421,P=0.017)。两组间患者治疗前1d,治疗后1d,1、2、6、12mo的视野平均阈值敏感度差异均无统计学意义(P>0.05)。两组患者治疗后1d的F-ERG a波振幅均低于治疗前1d,差异具有统计学意义(t=2.319,P=0.025)。两组间患者治疗前1d,治疗后1d,1、2、6、12mo的F-ERG a波振幅差异均无统计学意义(P>0.05)。两组患者治疗后1d的F-ERG b波振幅均低于治疗前1d,差异具有统计学意义(t=2.276,P=0.031)。两组间患者治疗前1d,治疗后1d,1、2、6、12mo的F-ERG b波振幅差异均无统计学意义( P>0.05)。两组患者的有效率、光斑数量差异均无统计学意义(P>0.05)。观察组的激光能量高于对照组,能量密度低于对照组,差异具有统计学意义(P<0.05)。 　　结论：给予非增生期糖尿病视网膜病变患者多点扫描一次完成PRP治疗与单点多次完成PRP治疗的临床疗效没有显著差异,但是多点扫描一次完成PRP的治疗方案能量密度较低,产生的激光损伤较小。
목적：비교격광다점소묘여단점다차소묘치료비증생기당뇨병시망막병변적료효。 　　방법：선취2010-01/2014-01기간아문수치적50례비증생기당뇨병시망막병변환자위연구대상,채용수궤수표법장50례환자분위관찰조화대조조,관찰조환자25례43안,채용577 nm격광다점소묘일차완성전시망막격광광응( PRP)치료,대조조환자25례41안,채용단점다차소묘완성PRP치료。대비량조환자불동시간적시야평균역치민감도、F-ERG a파진폭、F-ERG b파진폭,량조환자적림상유효솔、격광능량、광반수량、능량밀도。 　　결과：량조환자치료후1d적시야평균역치민감도균저우치료전1d,차이구유통계학의의(t=2.421,P=0.017)。량조간환자치료전1d,치료후1d,1、2、6、12mo적시야평균역치민감도차이균무통계학의의(P>0.05)。량조환자치료후1d적F-ERG a파진폭균저우치료전1d,차이구유통계학의의(t=2.319,P=0.025)。량조간환자치료전1d,치료후1d,1、2、6、12mo적F-ERG a파진폭차이균무통계학의의(P>0.05)。량조환자치료후1d적F-ERG b파진폭균저우치료전1d,차이구유통계학의의(t=2.276,P=0.031)。량조간환자치료전1d,치료후1d,1、2、6、12mo적F-ERG b파진폭차이균무통계학의의( P>0.05)。량조환자적유효솔、광반수량차이균무통계학의의(P>0.05)。관찰조적격광능량고우대조조,능량밀도저우대조조,차이구유통계학의의(P<0.05)。 　　결론：급여비증생기당뇨병시망막병변환자다점소묘일차완성PRP치료여단점다차완성PRP치료적림상료효몰유현저차이,단시다점소묘일차완성PRP적치료방안능량밀도교저,산생적격광손상교소。
AIM:To compare the curative effects between laser multi-point scanning and single-point multiple scanning for the treatment of non-proliferative diabetic retinopathy. METHODS:Fifty patients with non-proliferative diabetic retinopathy from January 2010 to January 2014 in our hospital were selected for the study, and were divided into two groups, the control group and the observation group, using a random number table. Twenty - five patients ( 43 eyes ) in the observation group completed panretinal photocoagulation ( PRP ) therapy once by 577nm laser multi-point scanning. Twenty-five patients (41 eyes) in the control group completed PRP therapy by the single-point multiple scanning. The differences of average threshold sensitivity of visual field, F-ERG a/b wave amplitude , the clinical effective rates, the laser energy, the number of laser spot and the energy density between the two groups at various time points were compared. RESULTS: At 1d after the treatments, average threshold sensitivity of visual field was lower than those at 1d before treament, and the difference was statistically significant ( t = 2. 421, P = 0. 017 ). The differences of average threshold sensitivity between the two groups at 1d before treatments, at 1d, 1, 2, 6, 12mo after treatments, were not statistically significant (P>0. 05). The F-ERG a wave amplitude of both groups at 1d after treatments were lower than those of 1d before treatments, and the difference was statistically significant (t=2.319, P=0.025). There were no differences of the F-ERG b wave amplitude between both groups at 1d before treatments and at 1d, 1, 2, 6, 12mo after treatments (P>0.05). The F-ERG b wave amplitude of both groups at 1d after treatments were lower than those at 1d before treatments, and the difference was statistically significant (t=2. 276, P=0. 031). There were no differences between the two groups in terms of clinical effective rates and the number of laser spot (P>0. 05). Laser energy used in the observation group was higher than that in the control group, the energy density was lower than that in the control group. The differences on the two items were statistically significant (P <0. 05). CONCLUSION:There is no significant difference on clinical efficacy between laser multi-point scanning and single-point multiple scanning of PRP therapy. But the energy density of multi-point scanning mode is lower, and the damage made by this mode is less.