CAJ | 학술논문

目的对滨州市老年人群中患肺痨的临床资料进行回顾性分析,探讨老年肺痨患者耐药菌群分布情况及导致耐药菌感染的危险因素.方法回顾性分析263例老年肺痨患者的临床资料,对患者耐药菌感染率、耐药菌群分布及导致耐药菌感染的危险因素进行分析.结果所有患者中,共有51例患者为耐药菌感染,感染率为19.39％.仅1种药物耐药者构成比最高,占45.10％(患者23例),其次为耐2种及3种药物者,均为23.53％(患者均为12例),耐4种药物者构成比最低,仅占7.84％(患者4例),存在统计学差异.同时耐异烟肼药物者构成比最高,占27.27％(患者27例),其次为耐利福平药物者,占22.22％(患者22例),而耐水杨酸药物者构成比最低,仅为6.66％(患者6例)同样存在统计学差异.药物依从性、吸烟及糖尿病病史均为导致社区老年人群患肺痨的危险因素(P＜0.05),而性别、年龄、身高、体重、病程及高血压病史均非导致社区老年人群患肺痨的危险因素(P＞0.05).结论社区老年肺痨患者的耐药菌感染发病率较高,且以单独一种药物耐药及耐异烟肼药物者居多,同时其发病与治疗中断、依从性差、吸烟及糖尿病病史密切相关,临床应注意以上因素.
목적 대빈주시노년인군중환폐로적림상자료진행회고성분석,탐토노년폐로환자내약균군분포정황급도치내약균감염적위험인소.방법 회고성분석263례노년폐로환자적림상자료,대환자내약균감염솔、내약균군분포급도치내약균감염적위험인소진행분석.결과 소유환자중,공유51례환자위내약균감염,감염솔위19.39％.부1충약물내약자구성비최고,점45.10％(환자23례),기차위내2충급3충약물자,균위23.53％(환자균위12례),내4충약물자구성비최저,부점7.84％(환자4례),존재통계학차이.동시내이연정약물자구성비최고,점27.27％(환자27례),기차위내리복평약물자,점22.22％(환자22례),이내수양산약물자구성비최저,부위6.66％(환자6례)동양존재통계학차이.약물의종성、흡연급당뇨병병사균위도치사구노년인군환폐로적위험인소(P＜0.05),이성별、년령、신고、체중、병정급고혈압병사균비도치사구노년인군환폐로적위험인소(P＞0.05).결론 사구노년폐로환자적내약균감염발병솔교고,차이단독일충약물내약급내이연정약물자거다,동시기발병여치료중단、의종성차、흡연급당뇨병병사밀절상관,림상응주의이상인소.
Objective To investigate elderly phthisis drug-resistant bacteria distribution in Binzhou and risk factors.Methods Retrospectively analyzed clinical data of 263 elderly phthisis patients.Drug-resistant bacteria infection,drug-resistant bacteria distribution and risk factors of drug-resistant bacteria infection were aalyzed.Results There were 51 cases of drug-resistant bacteria infection in all patients,with the infection rate of 19.39％.There was only one kind of drug resistance in 23 cases (45.10％),two,three kinds of drug resistance in 12 cases (23.53％),four kinds of drug resistance in 4 cases (7.84％).27 cases (27.27％) were resistant to isoniazid,22 cases (22.22％) resistant to rifampicin,and 6 cases (6.66％) resistant to salicylic acid.Drug compliance,the history of smoking and diabetes were risk factors of elderly phthisis in community (P＜0.05),while gender,age,height,weight,duration and the history of high blood pressure were not (P＞0.05).Conclusions The incidence of elderly phthisis drug-resistant bacteria infection in community is high,one kind of drug resistance and resistance to isoniazid are the most common.Elderly phthisis drug-resistant bacteria infection is closely related to interrupted treatment,bad compliance,the history of smoking and diabetes,which should be paid attention to.