CAJ | 학술논문

目的：探讨首发抑郁症患者瘦素、脂联素及抵抗素等血清脂肪因子的水平。方法：首发抑郁症患者60例纳入抑郁组，健康体检者40例纳入对照组，进行体脂参数及瘦素、脂联素和抵抗素水平的测定。结果：2组体脂参数差异无统计学意义（P＞0.05）。抑郁组血浆瘦素、脂联素浓度显著低于对照组（P<0.01），抵抗素浓度差异无统计学意义（P＞0.05）；2组内女性的瘦素水平均明显高于同组男性（P<0.01），不同性别患者脂联素和抵抗素差异无统计学意义（P＞0.05）。结论：首发抑郁症患者存在一定水平的瘦素和脂联素浓度异常。
목적：탐토수발억욱증환자수소、지련소급저항소등혈청지방인자적수평。방법：수발억욱증환자60례납입억욱조，건강체검자40례납입대조조，진행체지삼수급수소、지련소화저항소수평적측정。결과：2조체지삼수차이무통계학의의（P＞0.05）。억욱조혈장수소、지련소농도현저저우대조조（P<0.01），저항소농도차이무통계학의의（P＞0.05）；2조내녀성적수소수평균명현고우동조남성（P<0.01），불동성별환자지련소화저항소차이무통계학의의（P＞0.05）。결론：수발억욱증환자존재일정수평적수소화지련소농도이상。
Objective:The aim of this study is to investigate the serum levels of adipocytokines- leptin, adiponectin, and resistin in patients with first episode depression. Methods: Sixty patients with first episode depression (depres-sion group) and 40 healthy controls (control group) were enrolled. The serum levels of leptin, adiponectin, and re-sistin were measured in all the cases. Results: There was no significance in anthropometric parameters between the two groups (P>0.05). The serum levels of leptin and adiponectin in the depression group were significantly lower than those in the control group (P<0.01) and there was no significantly difference in serum level of resistin between the two groups (P>0.05). The serum level of leptin of females was higher than that of males in the both groups (P<0.01). There were no difference in the serum levels of adiponectin and resistin between female and male cases in the both groups (P>0.05). Conclusion: The serum levels of leptin and adiponectin in patients with first episode depres-sion are usually abnormal.