中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
35期
2837-2840
,共4页
胡浩梅%杨华%殷振惠%赵露
鬍浩梅%楊華%慇振惠%趙露
호호매%양화%은진혜%조로
稽留流产%外周血%绒毛%染色体
稽留流產%外週血%絨毛%染色體
계류유산%외주혈%융모%염색체
Missed abortion%Peripheral blood%Villi%Chromosome
目的 探讨稽留流产与染色体异常的关系,指导优生.方法 对象为2014年6月至2015年4月在天津市中心妇产科医院就诊稽留流产夫妇,共90对.采用静脉血淋巴细胞培养行染色体核型检查,并对其90例清宫绒毛通过高通量测序技术进行染色体检查.结果 90对夫妇外周血染色体异常者共7例,异常率为3.89％.其中相互平衡易位3例,罗氏易位2例,倒位2例.90例绒毛检测成功85例,检测成功率94.4％,其中染色体异常绒毛50例,包括数目异常39例,结构异常11例,总异常率为58.8％.此外,稽留流产复发组(≥2次)与首发组绒毛染色体异常率分别是61.7％和55.2％,两组比较P＞0.05.孕妇年龄≥35岁组绒毛染色体异常率71.1％,年龄＜35岁组45％,两组比较P＜0.05.结论 染色体异常是造成稽留流产的重要原因,绒毛染色体异常率与稽留流产次数无关,孕妇高龄是造成绒毛染色体异常的高危因素.
目的 探討稽留流產與染色體異常的關繫,指導優生.方法 對象為2014年6月至2015年4月在天津市中心婦產科醫院就診稽留流產伕婦,共90對.採用靜脈血淋巴細胞培養行染色體覈型檢查,併對其90例清宮絨毛通過高通量測序技術進行染色體檢查.結果 90對伕婦外週血染色體異常者共7例,異常率為3.89％.其中相互平衡易位3例,囉氏易位2例,倒位2例.90例絨毛檢測成功85例,檢測成功率94.4％,其中染色體異常絨毛50例,包括數目異常39例,結構異常11例,總異常率為58.8％.此外,稽留流產複髮組(≥2次)與首髮組絨毛染色體異常率分彆是61.7％和55.2％,兩組比較P＞0.05.孕婦年齡≥35歲組絨毛染色體異常率71.1％,年齡＜35歲組45％,兩組比較P＜0.05.結論 染色體異常是造成稽留流產的重要原因,絨毛染色體異常率與稽留流產次數無關,孕婦高齡是造成絨毛染色體異常的高危因素.
목적 탐토계류유산여염색체이상적관계,지도우생.방법 대상위2014년6월지2015년4월재천진시중심부산과의원취진계류유산부부,공90대.채용정맥혈림파세포배양행염색체핵형검사,병대기90례청궁융모통과고통량측서기술진행염색체검사.결과 90대부부외주혈염색체이상자공7례,이상솔위3.89％.기중상호평형역위3례,라씨역위2례,도위2례.90례융모검측성공85례,검측성공솔94.4％,기중염색체이상융모50례,포괄수목이상39례,결구이상11례,총이상솔위58.8％.차외,계류유산복발조(≥2차)여수발조융모염색체이상솔분별시61.7％화55.2％,량조비교P＞0.05.잉부년령≥35세조융모염색체이상솔71.1％,년령＜35세조45％,량조비교P＜0.05.결론 염색체이상시조성계류유산적중요원인,융모염색체이상솔여계류유산차수무관,잉부고령시조성융모염색체이상적고위인소.
Objective To investigate the relationship between the missed abortion and chromosome abnormality and guide the healthy birth.Methods From June 2014 to April 2015 in Tianjin central hospital of gynecology and obstetrics,we examined venous blood from 90 missed abortion couples for chromosome karyotype by lymphocyte culture method and we also examined their chromosome karyotype of abortion villus samples by high-throughput sequencing technologies.Results Out of the 90 couples' blood chromosome examinations,7 were abnormal,and the abnormal rate was 3.89％,including 3 cases reciprocal translocation,2 cases robertsonian translocation and 2 cases inversion.Abortion villus samples from the same population were also checked,of which 85 cases succeeded,with the success rate of 94.4％.Among them,villi chromosome abnormalities were found in 50 cases,including 39 cases with abnormal chromosome numbers,11 cases with abnormal chromosome structure,and the total abnormal rate was 58.8％.In addition,the villi chromosome abnormality rate of patients with recurrent missed abortion (≥ 2 times) and first missed abortion were 61.7％ and 55.2％,respectively,and the difference was not significant (P ＞ 0.05).The villi chromosome abnormality rate of pregnant women with age ≥ 35 years old was 71.1％,while the pregnant women with aged ＜ 35 years old was 45％ (P ＜ 0.05).Conclusions Chromosome abnormality is an important cause of missed abortion;villi chromosome abnormality rate has nothing to do with the number of missed abortion;pregnant woman with age ≥ 35 years old is risk factor of the villi chromosome abnormality.
