CAJ | 학술논문

滴眼液是眼科最主要的治疗制剂.多剂量的滴眼液中通常需要加入防腐剂,用以抑制病原微生物的生长和增加药物的稳定性.滴眼液使用不当可导致眼表损伤,甚至引起严重的视功能障碍,而滴眼液中所含有的防腐剂是导致这些损伤的最主要原因.最大限度避免或减少滴眼液对眼表的损伤已引起临床高度重视.然而,过分夸大防腐剂的危害也是目前需要正视的问题.正确认识滴眼液中的防腐剂,不仅可以避免其毒副作用,而且可综合考虑患者的眼病性质、眼表泪液状态、经济与文化背景、用药的方便程度及其成本与效益等多种因素,优选滴眼液,合理用药,最优利用防腐剂的优势.制定含防腐剂滴眼液的临床使用规范、广泛开展继续教育及开发理想的防腐剂,是此领域未来的发展方向.
적안액시안과최주요적치료제제.다제량적적안액중통상수요가입방부제,용이억제병원미생물적생장화증가약물적은정성.적안액사용불당가도치안표손상,심지인기엄중적시공능장애,이적안액중소함유적방부제시도치저사손상적최주요원인.최대한도피면혹감소적안액대안표적손상이인기림상고도중시.연이,과분과대방부제적위해야시목전수요정시적문제.정학인식적안액중적방부제,불부가이피면기독부작용,이차가종합고필환자적안병성질、안표루액상태、경제여문화배경、용약적방편정도급기성본여효익등다충인소,우선적안액,합리용약,최우이용방부제적우세.제정함방부제적안액적림상사용규범、엄범개전계속교육급개발이상적방부제,시차영역미래적발전방향.
Eye drops are the most commonly used preparations in ophthalmology.Preservatives are usually added in order to protect eye drops against pathogenic organisms and increase the solubility of the drugs in multi-dose containers.Ophthalmologists have paid a lot of attention to the preservatives in eye drops because they remain one of the main reasons for ocular surface damage,and even may lead to serious visual impairment in patients with inappropriate use of eye drops.However,it should be noted that the dangers of preservatives become overstated nowadays.It is necessary to completely evaluate the effects of preservatives in ophthalmic preparations,so that ophthalmologists can guide patients to correctly select eye drops containing preservatives and avoid dangerous side effects,according to their eye disease situation,state of tear function and ocular surface changes,cultural background and financial income,cost and benefit and convenience of the use of drugs,and other factors.The direction of the future development in this field is to establish the clinical guideline for use of eye drops containing preservatives,carry out continuing education courses on preservatives and develop ideal preservatives.