CAJ | 학술논문

将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗（IAC）组和静脉诱导化疗联合放疗（IVC）组。治疗后4周， IAC 组与 IVC 组的完全缓解（CR）率分别为94．0％、70．0％，差异有统计学意义（P ＜0．05）；治疗后12周，IAC 组与 IVC组的 CR 率分别为98．0％、72．0％，差异有统计学意义（P ＜0．05）。两组治疗有效率均为100％，均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较，差异无统计学意义（P ＞0．05）。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。
장국부만기비인암환자분위동맥관주화료연합방료（IAC）조화정맥유도화료연합방료（IVC）조。치료후4주， IAC 조여 IVC 조적완전완해（CR）솔분별위94．0％、70．0％，차이유통계학의의（P ＜0．05）；치료후12주，IAC 조여 IVC조적 CR 솔분별위98．0％、72．0％，차이유통계학의의（P ＜0．05）。량조치료유효솔균위100％，균미발현원처전이병례。량조지간3、4급급성독부반응발생솔비교，차이무통계학의의（P ＞0．05）。인차동맥관주유도화료연합후기동보방화료료효가고、안전。
LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P <0.05),and at 12 weeks,98.0% vs 72.0%,with statistical significance (P <0.05).The effective rate of the two groups was both 100%,and there was no distant metastasis.3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32.0% and 34.0%,respectively,without statistical significance (P >0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely.