安徽医科大学学报
安徽醫科大學學報
안휘의과대학학보
Acta Universitatis Medicinalis Anhui
2015年
11期
1693-1695
,共3页
定坤丹%子宫内膜异位症%肿瘤坏死因子-α%血管内皮生长因子
定坤丹%子宮內膜異位癥%腫瘤壞死因子-α%血管內皮生長因子
정곤단%자궁내막이위증%종류배사인자-α%혈관내피생장인자
DingKunDan%endometriosis%tumor necrosis factor alpha%vascular endothelial cell growth factor
自体子宫内膜移植法建立子宫内膜异位症(EMS)模型大鼠,比较给药前后移植物体积、大鼠血清中肿瘤坏死因子-α(TNF-α)水平、异位内膜中血管内皮生长因子(VEGF)的表达。经定坤丹治疗后移植物体积、血清 TNF-α水平、异位内膜中 VEGF 的表达与疾病模型组相比均明显下降,差异有统计学意义(P <0.05)。定坤丹对 EMS 模型大鼠的异位内膜生长有一定的抑制作用,其作用机制可能与血清 TNF-α水平降低和 VEGF 的表达减少有关。
自體子宮內膜移植法建立子宮內膜異位癥(EMS)模型大鼠,比較給藥前後移植物體積、大鼠血清中腫瘤壞死因子-α(TNF-α)水平、異位內膜中血管內皮生長因子(VEGF)的錶達。經定坤丹治療後移植物體積、血清 TNF-α水平、異位內膜中 VEGF 的錶達與疾病模型組相比均明顯下降,差異有統計學意義(P <0.05)。定坤丹對 EMS 模型大鼠的異位內膜生長有一定的抑製作用,其作用機製可能與血清 TNF-α水平降低和 VEGF 的錶達減少有關。
자체자궁내막이식법건립자궁내막이위증(EMS)모형대서,비교급약전후이식물체적、대서혈청중종류배사인자-α(TNF-α)수평、이위내막중혈관내피생장인자(VEGF)적표체。경정곤단치료후이식물체적、혈청 TNF-α수평、이위내막중 VEGF 적표체여질병모형조상비균명현하강,차이유통계학의의(P <0.05)。정곤단대 EMS 모형대서적이위내막생장유일정적억제작용,기작용궤제가능여혈청 TNF-α수평강저화 VEGF 적표체감소유관。
We built rats model of endometriosis applying autologus endometrial transplants to compare the graft vol-ume of the modeling rats before and after dosing,serum tumor necrosis factor alpha(TNF-α)levels in rats,and the expressions of vascular endothelial cell growth factor(VEGF)in ectopic endometrium.To compare with the control group,the graft volume of DingKunDan group was reduced and the serum TNF-αlevel declined ,and also the ex-pression of VEGF in ectopic endometrium was reduced.Their differences were statistically significant (P <0.05). DingKunDan can inhibit the growth of ectopic endometrium in endometrosis model rats.The mechanism may be re-lated to the decrease of the serum TNF-αlevel and the VEGF expression.