医学临床研究
醫學臨床研究
의학림상연구
Journal of Clinical Research
2015年
8期
1493-1496
,共4页
吴晓康%尹佳锋%张荣强%高宗强%张妮%孟昊%卢洁%李妙羡%王香玲%耿燕
吳曉康%尹佳鋒%張榮彊%高宗彊%張妮%孟昊%盧潔%李妙羨%王香玲%耿燕
오효강%윤가봉%장영강%고종강%장니%맹호%로길%리묘이%왕향령%경연
结核/诊断%CA-125 抗原%磷酸丙酮酸水合酶%抗原,肿瘤%癌胚抗原%诊断,鉴别
結覈/診斷%CA-125 抗原%燐痠丙酮痠水閤酶%抗原,腫瘤%癌胚抗原%診斷,鑒彆
결핵/진단%CA-125 항원%린산병동산수합매%항원,종류%암배항원%진단,감별
Tuberculosis/DI%CA-125 Antigen%Phosphopyruvate Hydratase%Antigens,Neoplasm%Carcinoem-bryonic Antigen%Diagnosis,Differential
【目的】探讨糖类抗原125(CA125),神经元特异性烯醇化酶(NSE),非小细胞肺癌相关抗原21-1(CYF21-1),癌胚抗原(CEA)四种肿瘤标志物在结核病患者的表达特征,分析其在临床鉴别诊断中的意义。【方法】收集本院临床确诊为结核疾病的患者145例,并收集60例肺肿瘤患者和60例健康对照人群,采用电化学免疫发光技术检测三组人群 CEA,NSE, CYF21-1 and CA125四种肿瘤标志物血清的含量；比较结核病患者与肺肿瘤患者和健康人群四种标志物的差异；比较肺结核、陈旧性肺结核和结核性胸膜炎三种类型结核患者四种标志物的差异；比较结核病患者血清样本与胸腹水样本四种标志物的差异。【结果】结核患者血清 NSE 和 CA125含量显著高于健康人群,且差异有显著性(P <0.05),其 CA125甚至显著高于肺肿瘤患者(P <0.05)；不同类型结核患者仅 CEA 存在差异(P <0.05)；其 CEA 和 NSE 在胸腹水样本含量显著高于血清样本(P <0.05),而 CYF21-1和 CA125在血清样本含量显著高于胸腹水样本(P <0.05)。【结论】CA125可作为结核疾病鉴别诊断的一项指标,采集血清样本检测其结果更加准确；NSE 也可作为结核疾病鉴别诊断的指标,但其最佳采集样本应选择胸腹水进行。
【目的】探討糖類抗原125(CA125),神經元特異性烯醇化酶(NSE),非小細胞肺癌相關抗原21-1(CYF21-1),癌胚抗原(CEA)四種腫瘤標誌物在結覈病患者的錶達特徵,分析其在臨床鑒彆診斷中的意義。【方法】收集本院臨床確診為結覈疾病的患者145例,併收集60例肺腫瘤患者和60例健康對照人群,採用電化學免疫髮光技術檢測三組人群 CEA,NSE, CYF21-1 and CA125四種腫瘤標誌物血清的含量；比較結覈病患者與肺腫瘤患者和健康人群四種標誌物的差異；比較肺結覈、陳舊性肺結覈和結覈性胸膜炎三種類型結覈患者四種標誌物的差異；比較結覈病患者血清樣本與胸腹水樣本四種標誌物的差異。【結果】結覈患者血清 NSE 和 CA125含量顯著高于健康人群,且差異有顯著性(P <0.05),其 CA125甚至顯著高于肺腫瘤患者(P <0.05)；不同類型結覈患者僅 CEA 存在差異(P <0.05)；其 CEA 和 NSE 在胸腹水樣本含量顯著高于血清樣本(P <0.05),而 CYF21-1和 CA125在血清樣本含量顯著高于胸腹水樣本(P <0.05)。【結論】CA125可作為結覈疾病鑒彆診斷的一項指標,採集血清樣本檢測其結果更加準確；NSE 也可作為結覈疾病鑒彆診斷的指標,但其最佳採集樣本應選擇胸腹水進行。
【목적】탐토당류항원125(CA125),신경원특이성희순화매(NSE),비소세포폐암상관항원21-1(CYF21-1),암배항원(CEA)사충종류표지물재결핵병환자적표체특정,분석기재림상감별진단중적의의。【방법】수집본원림상학진위결핵질병적환자145례,병수집60례폐종류환자화60례건강대조인군,채용전화학면역발광기술검측삼조인군 CEA,NSE, CYF21-1 and CA125사충종류표지물혈청적함량；비교결핵병환자여폐종류환자화건강인군사충표지물적차이；비교폐결핵、진구성폐결핵화결핵성흉막염삼충류형결핵환자사충표지물적차이；비교결핵병환자혈청양본여흉복수양본사충표지물적차이。【결과】결핵환자혈청 NSE 화 CA125함량현저고우건강인군,차차이유현저성(P <0.05),기 CA125심지현저고우폐종류환자(P <0.05)；불동류형결핵환자부 CEA 존재차이(P <0.05)；기 CEA 화 NSE 재흉복수양본함량현저고우혈청양본(P <0.05),이 CYF21-1화 CA125재혈청양본함량현저고우흉복수양본(P <0.05)。【결론】CA125가작위결핵질병감별진단적일항지표,채집혈청양본검측기결과경가준학；NSE 야가작위결핵질병감별진단적지표,단기최가채집양본응선택흉복수진행。
[Objective]To explore the significance and characteristics of four tumor markers like CEA,NSE,CYF211 and CA125 in clinical differentiation and diagnosis of patients with tuberculosis.[Methods]145 cases of patients with tuberculosis confirmed by clinic were collected,and 60 cases of patients with pulmonary tumor plus 60 cases of healthy control group were also collected.The ser-um content of the four tumor markers like CEA,NSE,CYF211 and CA125 of the three groups were detected by electrochemical fluo-rescence immunoassay;The situation of the four markers was compared within patients of tuberculosis,pulmonary tumor and the healthy control group respectively;The differences of the four markers were compared in patients with three kinds of tuberculosis like pulmonary tuberculosis,obsolete pulmonary tuberculosis and tuberculous pleurisy;The differences of the four markers in the sample of serum and in the sample of pleuroperitoneal effusion of tuberculosis patients were also compared.[Results]Contents of NSE and CA125 in serum of tuberculosis patients were obviously higher than those of the healthy control,and the difference is significant(P <0.05);CA125 of tuberculosis patients was even higher than that of pulmonary tumor patients (P <0.05);There were no difference a-mong patients with different kinds of tuberculosis with the exception of CEA(P <0.05);Contents of CEA and NSE in serum sample were significantly higher than those in pleuroperitoneal effusion(P <0.05),while contents of CYE211and CA125 in serum sample were remarkably higher than those in pleuroperitoneal effusion sample(P <0.05).[Conclusions]CA125 can be considered as an indica-tor of differentiation and diagnosis of tuberculosis.The result can be more accurate through the collection and detection of serum sam-ple.The results would be more accurate if serum sample is collected and detected.Besides,NSE can also be chosen as an indicator of differentiation and diagnosis of tuberculosis diseases,whose optimal originality of sample collection shall come from pleuroperitoneal ef-fusion.
