CAJ | 학술논문

目的：对比观察不同浓度的玻璃酸钠对干眼眼表变化的影响。 　　方法：制备新西兰兔干眼动物模型,使用1g/L玻璃酸钠和3g/L玻璃酸钠滴滴液治疗,分别作为低浓度治疗组(B组)和高浓度治疗组(C组),生理盐水治疗作为对照组(A组)。分别观察角膜荧光染色、泪液分泌试验、结膜杯状细胞及黏蛋白表达和组织学变化。 　　结果：治疗后D7和D14时,B组及C组角膜荧光染色评分低于A组(P<0.05),泪液分泌、杯状细胞密度及黏蛋白含量高于A组(P<0.05)。 C组角膜泪液分泌和杯状细胞密度高于B组(P<0.05)。与B组和C组相比较,A组角膜及结膜上皮细胞层变薄,角膜及结膜基质未见明显异常。 　　结论：玻璃酸钠能够改善干眼眼表损害,且高浓度治疗效果优于低浓度。
목적：대비관찰불동농도적파리산납대간안안표변화적영향。 　　방법：제비신서란토간안동물모형,사용1g/L파리산납화3g/L파리산납적적액치료,분별작위저농도치료조(B조)화고농도치료조(C조),생리염수치료작위대조조(A조)。분별관찰각막형광염색、루액분비시험、결막배상세포급점단백표체화조직학변화。 　　결과：치료후D7화D14시,B조급C조각막형광염색평분저우A조(P<0.05),루액분비、배상세포밀도급점단백함량고우A조(P<0.05)。 C조각막루액분비화배상세포밀도고우B조(P<0.05)。여B조화C조상비교,A조각막급결막상피세포층변박,각막급결막기질미견명현이상。 　　결론：파리산납능구개선간안안표손해,차고농도치료효과우우저농도。
AIM:To observe the effect of different concentrations of sodium hyaluronate on ocular surface change of dry eye.METHODS: New Zealand rabbits with dry eye was prepared and treated with 0. 1% and 0. 3% sodium hyaluronate drops fluid respectively, which were regarded as low concentration treatment group ( group B) and high concentration treatment group ( group C ) respectively. However, the rabbits treated with saline were regarded as control group ( group A ) . And then, corneal fluorescein staining, Schirmer test, conjunctival goblet cells, mucin expression and histological changes were observed. RESULTS: On D7 and D14 after treatment, corneal fluorescein staining scores were lower in group B and group C than that in group A ( P<0. 05 ). However, Schirmer test, goblet cell density and mucin content were higher in group B and group C than those in A group (P <0. 05). Tear secretion and goblet cell density were higher in Group C than those in group B (P<0. 05). Compared with group B and group C, the thicknesses of corneal and conjunctival epithelial cell layer were thinner in group A. There were not obvious abnormalities in corneal and conjunctival stroma in each group. CONCLUSION: The sodium hyaluronate can improve ocular surface damage of dry eye in New Zealand rabbits. The high concentration of sodium hyaluronate has better effect than low concentration.