肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
Cancer Research and Clinic
2015年
8期
568-571
,共4页
许萍萍%江明杰%陈学英%付迪
許萍萍%江明傑%陳學英%付迪
허평평%강명걸%진학영%부적
竞争性内源RNA%微小RNA%肿瘤进程
競爭性內源RNA%微小RNA%腫瘤進程
경쟁성내원RNA%미소RNA%종류진정
Competing endogenous RNA%microRNA%Cancer progression
蛋白编码转录组和假基因、长链非编码RNA和环形RNA等非编码转录组共同组成了竞争性内源RNA(ceRNA).ceRNA之间通过miRNA应答元件进行“对话”,竞争性结合miRNA,调节基因的转录后表达.越来越多的研究发现,ceRNA通过拮抗效应隔离miRNA,形成一个广泛的基因转录后调节网络,参与正常生理状态的维持及对肿瘤等疾病的发生、发展过程的调控.ceRNA对肿瘤进程的调控可分为正性调控及负性调控,结果因其所影响的miRNA种类及细胞类型而异.ceRNA对肿瘤进程的调控作用使其可能成为肿瘤临床诊治的新靶点.
蛋白編碼轉錄組和假基因、長鏈非編碼RNA和環形RNA等非編碼轉錄組共同組成瞭競爭性內源RNA(ceRNA).ceRNA之間通過miRNA應答元件進行“對話”,競爭性結閤miRNA,調節基因的轉錄後錶達.越來越多的研究髮現,ceRNA通過拮抗效應隔離miRNA,形成一箇廣汎的基因轉錄後調節網絡,參與正常生理狀態的維持及對腫瘤等疾病的髮生、髮展過程的調控.ceRNA對腫瘤進程的調控可分為正性調控及負性調控,結果因其所影響的miRNA種類及細胞類型而異.ceRNA對腫瘤進程的調控作用使其可能成為腫瘤臨床診治的新靶點.
단백편마전록조화가기인、장련비편마RNA화배형RNA등비편마전록조공동조성료경쟁성내원RNA(ceRNA).ceRNA지간통과miRNA응답원건진행“대화”,경쟁성결합miRNA,조절기인적전록후표체.월래월다적연구발현,ceRNA통과길항효응격리miRNA,형성일개엄범적기인전록후조절망락,삼여정상생리상태적유지급대종류등질병적발생、발전과정적조공.ceRNA대종류진정적조공가분위정성조공급부성조공,결과인기소영향적miRNA충류급세포류형이이.ceRNA대종류진정적조공작용사기가능성위종류림상진치적신파점.
Protein-coding transcriptome,pseudogenes,long non-coding RNAs and circular RNAs can act as competing endogenous RNA (ceRNA).ceRNA can crosstalk with each other through microRNA recognition elements (MRE),thus regulating the post-transcriptional gene expression.More and more evidences showed that ceRNA could form an extensive network of post-transcription regulation,keep the cell homeostasis and involve in the disease development and progression like tumorigenesis and cancer progression.Depending on up-regulation or down-regulation of different kinds of microRNA in different cells,ceRNA acts as either an oncogene or a tumor suppressor.ceRNA may have a great potential in cancer diagnosis and treatment.