CAJ | 학술논문

蛋白编码转录组和假基因、长链非编码RNA和环形RNA等非编码转录组共同组成了竞争性内源RNA(ceRNA).ceRNA之间通过miRNA应答元件进行“对话”,竞争性结合miRNA,调节基因的转录后表达.越来越多的研究发现,ceRNA通过拮抗效应隔离miRNA,形成一个广泛的基因转录后调节网络,参与正常生理状态的维持及对肿瘤等疾病的发生、发展过程的调控.ceRNA对肿瘤进程的调控可分为正性调控及负性调控,结果因其所影响的miRNA种类及细胞类型而异.ceRNA对肿瘤进程的调控作用使其可能成为肿瘤临床诊治的新靶点.
단백편마전록조화가기인、장련비편마RNA화배형RNA등비편마전록조공동조성료경쟁성내원RNA(ceRNA).ceRNA지간통과miRNA응답원건진행“대화”,경쟁성결합miRNA,조절기인적전록후표체.월래월다적연구발현,ceRNA통과길항효응격리miRNA,형성일개엄범적기인전록후조절망락,삼여정상생리상태적유지급대종류등질병적발생、발전과정적조공.ceRNA대종류진정적조공가분위정성조공급부성조공,결과인기소영향적miRNA충류급세포류형이이.ceRNA대종류진정적조공작용사기가능성위종류림상진치적신파점.
Protein-coding transcriptome,pseudogenes,long non-coding RNAs and circular RNAs can act as competing endogenous RNA (ceRNA).ceRNA can crosstalk with each other through microRNA recognition elements (MRE),thus regulating the post-transcriptional gene expression.More and more evidences showed that ceRNA could form an extensive network of post-transcription regulation,keep the cell homeostasis and involve in the disease development and progression like tumorigenesis and cancer progression.Depending on up-regulation or down-regulation of different kinds of microRNA in different cells,ceRNA acts as either an oncogene or a tumor suppressor.ceRNA may have a great potential in cancer diagnosis and treatment.