医学临床研究
醫學臨床研究
의학림상연구
Journal of Clinical Research
2015年
8期
1477-1479
,共3页
脑源性神经营养因子/代谢%受体蛋白质酪氨酸激酶类/代谢%子宫内膜肿瘤/病理学%免疫组织化学
腦源性神經營養因子/代謝%受體蛋白質酪氨痠激酶類/代謝%子宮內膜腫瘤/病理學%免疫組織化學
뇌원성신경영양인자/대사%수체단백질락안산격매류/대사%자궁내막종류/병이학%면역조직화학
Brain-Derived Neurotrophic Factor/ME%Receptor Protein-Tyrosine Kinases/ME%En-dometrial Neoplasms/PA%Immunohistochemistry
【目的】探讨脑源性神经生长因子(Brain derived neurotrophic factor,BDNF)及酪氨酸激酶受体 B (tyrosine kinase receptor B,TrkB)在子宫内膜癌(endometrial carcinoma,EC)中的表达及其意义。【方法】采用免疫组织化检测22例正常子宫内膜(正常组)、32例增生子宫内膜(增生组)、62例 EC 组织(EC 组)中的BDNF 及 TrkB 表达水平,并分析 EC 组织中 BDNF、TrkB 的表达与其临床病理特征的关系。【结果】增生组、EC 组 BDNF、TrkB 阳性表达率显著高于正常组,而 EC 组 BDNF、TrkB 阳性表达率显著高于增生组,差异均有统计学意义(P <0.05)。EC 组织中 BDNF、TrkB 的表达与肿瘤细胞分化程度、临床病理分期、肌层浸润深度、淋巴结转移的有无均显著相关(P <0.05),且 EC 组织中 BDNF 与 TrkB 的表达具有显著相关性(r =0.508,P <0.05)。【结论】BDNF 及 TrkB 在 EC 的发生、发展中起重要作用,且两者相互促进。
【目的】探討腦源性神經生長因子(Brain derived neurotrophic factor,BDNF)及酪氨痠激酶受體 B (tyrosine kinase receptor B,TrkB)在子宮內膜癌(endometrial carcinoma,EC)中的錶達及其意義。【方法】採用免疫組織化檢測22例正常子宮內膜(正常組)、32例增生子宮內膜(增生組)、62例 EC 組織(EC 組)中的BDNF 及 TrkB 錶達水平,併分析 EC 組織中 BDNF、TrkB 的錶達與其臨床病理特徵的關繫。【結果】增生組、EC 組 BDNF、TrkB 暘性錶達率顯著高于正常組,而 EC 組 BDNF、TrkB 暘性錶達率顯著高于增生組,差異均有統計學意義(P <0.05)。EC 組織中 BDNF、TrkB 的錶達與腫瘤細胞分化程度、臨床病理分期、肌層浸潤深度、淋巴結轉移的有無均顯著相關(P <0.05),且 EC 組織中 BDNF 與 TrkB 的錶達具有顯著相關性(r =0.508,P <0.05)。【結論】BDNF 及 TrkB 在 EC 的髮生、髮展中起重要作用,且兩者相互促進。
【목적】탐토뇌원성신경생장인자(Brain derived neurotrophic factor,BDNF)급락안산격매수체 B (tyrosine kinase receptor B,TrkB)재자궁내막암(endometrial carcinoma,EC)중적표체급기의의。【방법】채용면역조직화검측22례정상자궁내막(정상조)、32례증생자궁내막(증생조)、62례 EC 조직(EC 조)중적BDNF 급 TrkB 표체수평,병분석 EC 조직중 BDNF、TrkB 적표체여기림상병리특정적관계。【결과】증생조、EC 조 BDNF、TrkB 양성표체솔현저고우정상조,이 EC 조 BDNF、TrkB 양성표체솔현저고우증생조,차이균유통계학의의(P <0.05)。EC 조직중 BDNF、TrkB 적표체여종류세포분화정도、림상병리분기、기층침윤심도、림파결전이적유무균현저상관(P <0.05),차 EC 조직중 BDNF 여 TrkB 적표체구유현저상관성(r =0.508,P <0.05)。【결론】BDNF 급 TrkB 재 EC 적발생、발전중기중요작용,차량자상호촉진。
[Objective]To explore the expressions of brain-derived neurotrophic factor (BDNF)and tyro-sine kinase receptor B (TrkB)in endometrial carcinoma and analyze their clinical significances.[Methods]The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n = 22), hyperplasia endometrium (n =32)and endometrial carcinoma (n =62).And the relationship with their clini-copathological characteristics were analyzed.[Results]BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma.And statistically significant differences existed among three groups (P < 0.05 ).The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation,clinicopathologic staging,myometrial invasion and lymph node metastasis of endometrial carcinoma (P <0.05).[Conclusion]The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.
