CAJ | 학술논문

目的：探讨影响病毒性脑炎（VE）患者发生癫痫的相关因素。方法：收集成人 VE 患者159例临床资料并进行随访，分析一般情况、发热、意识障碍程度、癫痫发作频率、神经系统阳性体征、脑脊液、病原学和脑电图等辅助检查结果，探讨 VE 恢复期癫痫发生的相关因素。结果：随访中34例（21.4%）出现继发性癫痫，纳入病例组，其中19例（55.9%）最终发展为难治性癫痫；未发生 PEE 患者125例（78.6%），纳入对照组。2组急性期意识障碍、癫痫反复发作和持续状态、大脑皮质损害、局灶性脑电图异常和脑脊液单纯疱疹病毒阳性差异具有统计学意义（P＜0.05）。结论：VE 急性期意识障碍、癫痫反复发作、癫痫持续状态、大脑皮质损害、局灶性脑电图异常和脑脊液单纯疱疹病毒阳性可能是恢复期继发性癫痫的相关因素。
목적：탐토영향병독성뇌염（VE）환자발생전간적상관인소。방법：수집성인 VE 환자159례림상자료병진행수방，분석일반정황、발열、의식장애정도、전간발작빈솔、신경계통양성체정、뇌척액、병원학화뇌전도등보조검사결과，탐토 VE 회복기전간발생적상관인소。결과：수방중34례（21.4%）출현계발성전간，납입병례조，기중19례（55.9%）최종발전위난치성전간；미발생 PEE 환자125례（78.6%），납입대조조。2조급성기의식장애、전간반복발작화지속상태、대뇌피질손해、국조성뇌전도이상화뇌척액단순포진병독양성차이구유통계학의의（P＜0.05）。결론：VE 급성기의식장애、전간반복발작、전간지속상태、대뇌피질손해、국조성뇌전도이상화뇌척액단순포진병독양성가능시회복기계발성전간적상관인소。
Objective: To investigate the related factors for the occurrence of postencephalitic epilepsy (PEE) in patients with viral encephalitis (VE). Methods: One hundred and fifty-nine cases with VE in adults were followed up. The clinical data including general condition, fever, consciousness level, seizure frequency, focal neurological sign, cerebrospinal fluid parameter, central nervous system infection and electroencephalography findings were analyzed. Results: Of the total 159 patients, 34 (21.4%) were found to develope epilepsy (case group), in which 19 (55.9%) harbored refractory epilepsy. There was significant difference in consciousness level, seizure frequency, focal cortical abnormalities, focal cerebral dysfunction and herpes simplex virus infection during the acute phase between the epileptic cases and the cases without epilepsy (P<0.05). Conclusion: The presence of coma, recurrent seizures or status epilepticus, focal cortical abnormalities in neuroimaging, focal cerebral dysfunction in electroencephalography and herpes simplex virus infection during the acute phase of VE are potential risk factors of PEE.