CAJ | 학술논문

目的：观察子宫内膜癌组织中趋化因子 CXCL12及其受体 CXCR4表达水平，探讨其与子宫内膜癌患者临床病理特征相关性。方法收集2012年1月～2014年12月间入院接受手术的子宫内膜癌患者52例病理标本，年龄55.6±19.2岁，以正常子宫内膜26例为对照组，年龄52.3±16.5岁。采用免疫组化技术检测趋化因子 CXCL12及其受体 CX-CR4在子宫内膜癌组织中的表达情况，并分析它们与 FIGO 分期、细胞分化程度、淋巴结转移和病理类型等临床病理特征的关系。结果CXCL12和 CXCR4在子宫内膜癌组织中阳性表达率分别为76.92％和69.23％，而在正常子宫内膜组织中则分别为34.62％和30.77％，差异具有统计学意义（χ2＝11.826，P ＜0.01）。CXCR4的表达与子宫内膜癌细胞分化程度存在差异，有统计学意义（均 P ＜0.05），且与分化高低呈正相关（r＝0.386，P ＜0.05）。在子宫内膜癌组织中，除 CXCR4表达与细胞分化程度呈正相关外，CXCL12和 CXCR4表达与临床分期、淋巴结转移和病理类型无相关性（P ＞0.05）。结论CXCL12和 CXCR4在子宫内膜癌组织中表达明显升高，这可能在子宫内膜癌发生发展过程中发挥重要生物学作用。
목적：관찰자궁내막암조직중추화인자 CXCL12급기수체 CXCR4표체수평，탐토기여자궁내막암환자림상병리특정상관성。방법수집2012년1월～2014년12월간입원접수수술적자궁내막암환자52례병리표본，년령55.6±19.2세，이정상자궁내막26례위대조조，년령52.3±16.5세。채용면역조화기술검측추화인자 CXCL12급기수체 CX-CR4재자궁내막암조직중적표체정황，병분석타문여 FIGO 분기、세포분화정도、림파결전이화병리류형등림상병리특정적관계。결과CXCL12화 CXCR4재자궁내막암조직중양성표체솔분별위76.92％화69.23％，이재정상자궁내막조직중칙분별위34.62％화30.77％，차이구유통계학의의（χ2＝11.826，P ＜0.01）。CXCR4적표체여자궁내막암세포분화정도존재차이，유통계학의의（균 P ＜0.05），차여분화고저정정상관（r＝0.386，P ＜0.05）。재자궁내막암조직중，제 CXCR4표체여세포분화정도정정상관외，CXCL12화 CXCR4표체여림상분기、림파결전이화병리류형무상관성（P ＞0.05）。결론CXCL12화 CXCR4재자궁내막암조직중표체명현승고，저가능재자궁내막암발생발전과정중발휘중요생물학작용。
Objective To observe the translations of chemokine CXCL12 and its receptor CXCR4 in endometrial carcinoma tissues,and to evaluate their significance in clinical pathologic features of endometrial carcinoma.Methods From Jan.2012 to Dec.2014,52 tissue specimens of patients with endometrial carcinoma were admitted to the hospital,aged 55.6 ± 19.2 years,and 26 cases of normal endometrium as control,aged 52.3±16.5 years old.Expressions of CXCL12 and CXCR4 in the tissue specimens were detected by immunohistochemistry,and to analyze the relationship between the expressions and clini-cal pathological features,and FIGO stage,cell differentiation,lymph node metastasis and pathological type in endometrial carcinoma.Results In endometrial carcinoma,the positivity rates of CXCR4 and CXCL12 were 76.92% and 69.23% re-spectively.The positive expression rates of which were 34.62% and 30.77% in normal endometrium tissues,statistically significant (χ2 =11.826,P <0.01).The expression of CXCR4 was positively correlated with the differentiation of endome-trial carcinoma cells (P <0.05).In endometrial carcinoma,with the exception of CXCR4 expression and cell differentiation was positively related (r=0.386,P <0.05),CXCL12 and CXCR4 expression and clinical stage,pathological type and lymph node metastasis no correlation was found (P >0.05).Conclusion The results showed that the expression of CXCL12 and CXCR4 in endometrial carcinoma tissues was significantly increased,which may play an important role in the development of endometrial cancer.