CAJ | 학술논문

目的：探讨联合检测人附睾蛋白4（HE4）、糖类抗原125（CA125）和糖类抗原199（CA199）在卵巢癌和良性卵巢囊肿中的应用价值。方法采用化学发光免疫分析法检测45例原发性卵巢癌患者（卵巢癌组）、60例良性卵巢囊肿患者（良性疾病组）和30例体检健康者（对照组）血清HE4、CA125和CA199水平，并进行比较分析。结果卵巢癌组患者血清 HE4、CA125和CA199水平均高于良性疾病组与对照组，差异均有统计学意义（P＜0．05）；良性疾病组患者血清CA125水平高于对照组，差异有统计学意义（P＜0．05），但血清HE4、CA199水平与对照组比较差异均无统计学意义（P＞0．05）；三者联合检测用于诊断卵巢癌患者的灵敏度提高到82．2％，而特异度也保持在90．0％。结论联合检测HE4、CA125和CA199对卵巢癌的早期诊断及鉴别具有重要的临床意义。
목적：탐토연합검측인부고단백4（HE4）、당류항원125（CA125）화당류항원199（CA199）재란소암화량성란소낭종중적응용개치。방법채용화학발광면역분석법검측45례원발성란소암환자（란소암조）、60례량성란소낭종환자（량성질병조）화30례체검건강자（대조조）혈청HE4、CA125화CA199수평，병진행비교분석。결과란소암조환자혈청 HE4、CA125화CA199수평균고우량성질병조여대조조，차이균유통계학의의（P＜0．05）；량성질병조환자혈청CA125수평고우대조조，차이유통계학의의（P＜0．05），단혈청HE4、CA199수평여대조조비교차이균무통계학의의（P＞0．05）；삼자연합검측용우진단란소암환자적령민도제고도82．2％，이특이도야보지재90．0％。결론연합검측HE4、CA125화CA199대란소암적조기진단급감별구유중요적림상의의。
Objective To explore the clinical value of combined detection of human epididymis protein 4(HE4) ,carbohydrate an‐tigen 199(CA199) and carbohydrate antigen 125(CA125) in diagnosis of ovarian cancer and benign ovarian cysts .Methods The se‐rum levels of HE4 ,CA125 and CA199 were determined by using chemiluminescent immunoassay in 45 cases of patients with ovarian cancer(ovarian cancer group) ,60 cases of patients with benign ovarian cyst(benign disease group) ,and 30 cases of healthy individu‐al(control group) .Results The serum levels of HE4 ,CA199 and CA125 in the ovarian cancer group were higher than those in the ovarian cancer group and control group ,there were statistically significant differences(P<0 .05) .Compared with the control group , the serum level of CA125 in benign disease group was significantly higher(P<0 .05) ,while no statistically significant differences of serum levels of HE4 and CA199 were observed between the two groups(P>0 .05) .The sensitivity of combined detection of the three indicators increased to 82 .2% ,and the specificity remained at 90 .0% .Conclusion Combined detection of HE4 ,CA125 and CA199 might have clinical significance in early diagnosis and identification of ovarian cancer .