CAJ | 학술논문

目的：探讨妊娠晚期孕妇血清肝功能指标的变化及正常参考区间，并分析其临床意义。方法选取该院2013年7月至2014年6月妊娠晚期孕妇4659例，健康非孕女性3089例，采用全自动生化分析仪检测血清谷氨酸氨基转移酶（ALT ）、丙氨酸氨基转移酶（AST）、总蛋白（TP）、清蛋白（Alb）、前清蛋白（PA）、总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）、γ‐谷氨酰基转移酶（GGT）、总胆汁酸（TBA）、天门冬氨酸氨基转移酶线粒体同工酶（m‐AST）、碱性磷酸酶（ALP）水平。结果与健康非孕女性比较，妊娠晚期孕妇血清ALT、AST、TP、Alb、PA、TBIL、DBIL、IBIL、GGT水平均降低，而血清ALP、m‐AST、TBA水平均升高，差异均有统计学意义（P＜0．05）。结论妊娠晚期孕妇肝功能指标明显不同于非妊娠女性，各临床实验室应建立妊娠各期肝功能指标参考区间，有助于评价产妇营养及肝功能状态，做好孕期保健工作。
목적：탐토임신만기잉부혈청간공능지표적변화급정상삼고구간，병분석기림상의의。방법선취해원2013년7월지2014년6월임신만기잉부4659례，건강비잉녀성3089례，채용전자동생화분석의검측혈청곡안산안기전이매（ALT ）、병안산안기전이매（AST）、총단백（TP）、청단백（Alb）、전청단백（PA）、총담홍소（TBIL）、직접담홍소（DBIL）、간접담홍소（IBIL）、γ‐곡안선기전이매（GGT）、총담즙산（TBA）、천문동안산안기전이매선립체동공매（m‐AST）、감성린산매（ALP）수평。결과여건강비잉녀성비교，임신만기잉부혈청ALT、AST、TP、Alb、PA、TBIL、DBIL、IBIL、GGT수평균강저，이혈청ALP、m‐AST、TBA수평균승고，차이균유통계학의의（P＜0．05）。결론임신만기잉부간공능지표명현불동우비임신녀성，각림상실험실응건립임신각기간공능지표삼고구간，유조우평개산부영양급간공능상태，주호잉기보건공작。
Objective To explore changes of serum levels of liver function indicators and their reference intervals in pregnant women in the last trimester of pregnancy ,and to analyse its clinical significance .Methods From July 2013 to June 2014 ,a total of 4 659 cases of pregnant women in the last trimester of pregnancy and 3 089 healthy non‐pregnant women were enrolled in this stud‐y .Serum levels of alanine aminotransferase(ALT) ,aspartatre transaminase(AST) ,total protein(TP) ,albumin(Alb) ,pre‐albumin (PA) ,total bilrubin(TBIL) ,direct bilrubin(DBIL) ,indirect bilrubin(IBIL) ,γ‐glutamyl transpeptidase(GGT)and mitochondrial as‐partate aminotransferase(m‐AST) were determined by fully automatic biochemical analyzer .Results Compared with healthy non‐pregnant women ,serum levels of ALT ,AST ,TP ,Alb ,PA ,TBIL ,DBIL ,IBIL and GGT were significantly decreased ,while serum le‐vers of ALP ,m‐AST and TBA were significantly increased in pregnant women in the last trimester of pregnancy ,there were statis‐tically significant differences(P<0 .05) .Conclusion This study suggested that the liver functions of pregnant women were signifi‐cantly different from healthy non‐pregnant women .Each clinical laboratory should establish reference intervals of liver function indi‐cators for pregnant women at each stage of pregnancy ,so as to timely ,correctly and reasonably evaluate their liver functions and material nutrition status ,and provide better antenatal care services .