CAJ | 학술논문

目的：观察降糖对药方对糖尿病患者血脂水平的改善效果。方法选择2012年3月—2014年12月河北临漳县医院和新疆和静县人民医院门诊糖尿病患者327例，所有患者除继续接受饮食、运动疗法及原先使用之药物外，均接受降糖方治疗，每日一剂，分2次口服，疗程三个月。观察治疗前后甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血清脂蛋白α（Lpα）、载脂蛋白A（ApoA）和载脂蛋白B（ApoB）的变化情况。结果本组治疗后低密度脂蛋白胆固醇、胆固醇、血清脂蛋白α显著降低，高密度脂蛋白胆固醇升高，与治疗前比较差异均有统计学意义（P<0.01，P<0.05），甘油三酯、载脂蛋白A和载脂蛋白B变化差异无统计学意义（P>0.05）。无药物不良反应。结论降糖对药方可改善糖尿病患者的血脂水平，且使用安全。
목적：관찰강당대약방대당뇨병환자혈지수평적개선효과。방법선택2012년3월—2014년12월하북림장현의원화신강화정현인민의원문진당뇨병환자327례，소유환자제계속접수음식、운동요법급원선사용지약물외，균접수강당방치료，매일일제，분2차구복，료정삼개월。관찰치료전후감유삼지（TG）、담고순（TC）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、혈청지단백α（Lpα）、재지단백A（ApoA）화재지단백B（ApoB）적변화정황。결과본조치료후저밀도지단백담고순、담고순、혈청지단백α현저강저，고밀도지단백담고순승고，여치료전비교차이균유통계학의의（P<0.01，P<0.05），감유삼지、재지단백A화재지단백B변화차이무통계학의의（P>0.05）。무약물불량반응。결론강당대약방가개선당뇨병환자적혈지수평，차사용안전。
Objective: To observe the effect of lowering blood glucose on blood lipid level in patients with diabetes mellitus. Methods: from March 2012 ~2014 to December, 327 patients with diabetes in Linzhang People's Hospital, Hebei and Xinjiang, and all patients were treated with hypoglycemic agents except for continuing to receive diet, exercise therapy, and the original drug. The changes of triglyceride (TG), cholesterol (Lp), cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), lipoprotein A (ApoA), apolipoprotein B (ApoB) were observed.Results: the low density lipoprotein cholesterol, cholesterol, serum lipoprotein cholesterol and serum lipoprotein cholesterol were significantly lower in the group treated with low density lipoprotein cholesterol, high density lipoprotein cholesterol (P<0.01), the difference was statistically significant (P<0.05,), triglyceride, apolipoprotein A and apolipoprotein B changes were not statistically significant (P>0.05). No adverse drug reactions. Conclusion: lowering blood glucose to the prescription can improve the blood lipid level of diabetic patients, and use safety.