天津大学学报（英文版）
天津大學學報（英文版）
천진대학학보（영문판）
Transactions of Tianjin University
2015年
5期
383-391
,共9页
何志敏%张茜青%齐崴%黄仁亮%苏荣欣
何誌敏%張茜青%齊崴%黃仁亮%囌榮訢
하지민%장천청%제외%황인량%소영흔
alginate%casein%microencapsulation%response surface methodology%bioactive peptides
The aim of this work was to develop an alginate-casein composite microsphere as a bioactive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94%after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectra.
