南方医科大学学报
南方醫科大學學報
남방의과대학학보
Journal of Southern Medical University
2015年
9期
1349-1351
,共3页
白洁%邹兴伟%姜友贵%王琼玉
白潔%鄒興偉%薑友貴%王瓊玉
백길%추흥위%강우귀%왕경옥
瞬时感受器电位离子通道香草素受体亚家族4%寻常型天疱疮%大疱性类天疱疮%疱疹样皮炎%获得性大疱性表皮松解症
瞬時感受器電位離子通道香草素受體亞傢族4%尋常型天皰瘡%大皰性類天皰瘡%皰疹樣皮炎%穫得性大皰性錶皮鬆解癥
순시감수기전위리자통도향초소수체아가족4%심상형천포창%대포성류천포창%포진양피염%획득성대포성표피송해증
transient receptor potential vanilloid receptor4%pemphigus vulgaris%bullous pemphigoid%dermatitis herpetifor-mis%epidermolysis bullosa acquisita
目的：探讨TRPV4蛋白在寻常型天疱疮（PV）、大疱性类天疱疮（BP）、疱疹样皮炎（DH）、获得性大疱性表皮松解症（EBA）中的作用机制。方法用免疫组化方法检测正常皮肤组织、PV、BP、DH及EBA皮损组织中TRPV4蛋白的表达量。结果 TRPV4在PV（61.90%）、BP（81.81%）、DH（72.22%）、EBA（68.42%）的阳性率均低于正常皮肤组织（93.33%），且各类疾病间亦存在表达差异（PV<EBA<DH<BP）。结论 TRPV4蛋白的低表达可能影响着皮肤连接的形成或修复，参与皮肤免疫性大疱病的发生、发展。
目的：探討TRPV4蛋白在尋常型天皰瘡（PV）、大皰性類天皰瘡（BP）、皰疹樣皮炎（DH）、穫得性大皰性錶皮鬆解癥（EBA）中的作用機製。方法用免疫組化方法檢測正常皮膚組織、PV、BP、DH及EBA皮損組織中TRPV4蛋白的錶達量。結果 TRPV4在PV（61.90%）、BP（81.81%）、DH（72.22%）、EBA（68.42%）的暘性率均低于正常皮膚組織（93.33%），且各類疾病間亦存在錶達差異（PV<EBA<DH<BP）。結論 TRPV4蛋白的低錶達可能影響著皮膚連接的形成或脩複，參與皮膚免疫性大皰病的髮生、髮展。
목적：탐토TRPV4단백재심상형천포창（PV）、대포성류천포창（BP）、포진양피염（DH）、획득성대포성표피송해증（EBA）중적작용궤제。방법용면역조화방법검측정상피부조직、PV、BP、DH급EBA피손조직중TRPV4단백적표체량。결과 TRPV4재PV（61.90%）、BP（81.81%）、DH（72.22%）、EBA（68.42%）적양성솔균저우정상피부조직（93.33%），차각류질병간역존재표체차이（PV<EBA<DH<BP）。결론 TRPV4단백적저표체가능영향착피부련접적형성혹수복，삼여피부면역성대포병적발생、발전。
Objective To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA), and explore the role of TRPV4 in the pathogenesis of these diseases. Methods TRPV4 protein in normal skin tissues and lesions of PV, BP, DH, and EBA were detected with immunohistochemistry. Results The positivity rate of TRPV4 protein expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<DH<BP). Conclusion Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may play an role in the occurrence and development of autoimmune bullous skin disorders.
