国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
International Journal of Laboratory Medicine
2015年
18期
2652-2653
,共2页
万古霉素%肾毒性%主动监测
萬古黴素%腎毒性%主動鑑測
만고매소%신독성%주동감측
vancomycin%nephrotoxicity%active monitoring
目的:探讨万古霉素相关肾毒性主动监测的可行性和关键性。方法选取2010年7月至2013年7月经静脉注射万古霉素的住院患者139例,采取相关药品不良事件主动监测和评估警示体系,对提示有万古霉素阳性事件患者进行评价。结果139例患者中共有9例出现肾损害,肾功能不全代偿期、肾功能不全失代偿期、肾衰竭期、肾衰竭终末期的发生率分别是44.44%、22.22%、22.22%、11.11%。且血清肌酐在133μmol/L以上、血清肌酐较基线增加50%、血肌酐较基线增加44μmol/L的阳性预警率分别为55.56%、22.22%、22.22%,其在人工关联性评价结果中分别为19.18%、19.18%、56.54%。结论应根据患者病情等进行个体化万古霉素使用设置。
目的:探討萬古黴素相關腎毒性主動鑑測的可行性和關鍵性。方法選取2010年7月至2013年7月經靜脈註射萬古黴素的住院患者139例,採取相關藥品不良事件主動鑑測和評估警示體繫,對提示有萬古黴素暘性事件患者進行評價。結果139例患者中共有9例齣現腎損害,腎功能不全代償期、腎功能不全失代償期、腎衰竭期、腎衰竭終末期的髮生率分彆是44.44%、22.22%、22.22%、11.11%。且血清肌酐在133μmol/L以上、血清肌酐較基線增加50%、血肌酐較基線增加44μmol/L的暘性預警率分彆為55.56%、22.22%、22.22%,其在人工關聯性評價結果中分彆為19.18%、19.18%、56.54%。結論應根據患者病情等進行箇體化萬古黴素使用設置。
목적:탐토만고매소상관신독성주동감측적가행성화관건성。방법선취2010년7월지2013년7월경정맥주사만고매소적주원환자139례,채취상관약품불량사건주동감측화평고경시체계,대제시유만고매소양성사건환자진행평개。결과139례환자중공유9례출현신손해,신공능불전대상기、신공능불전실대상기、신쇠갈기、신쇠갈종말기적발생솔분별시44.44%、22.22%、22.22%、11.11%。차혈청기항재133μmol/L이상、혈청기항교기선증가50%、혈기항교기선증가44μmol/L적양성예경솔분별위55.56%、22.22%、22.22%,기재인공관련성평개결과중분별위19.18%、19.18%、56.54%。결론응근거환자병정등진행개체화만고매소사용설치。
Objective To explore the feasibility and importance of active monitoring of vancomycin‐related nephrotoxicity .Meth‐ods During July 2010 to July 2013 ,a total of 139 cases of inpatients received vancomycin through intravenous injection were en‐rolled in this study .The adverse drug reaction active monitoring and early warning system were utilized to evaluate patients with vancomycin positive events .Results Among the 139 cases of patients ,there was 9 cases of patients with renal damage .The inci‐dences of compensatory stage of renal insufficiency ,decompensatory stage of renal insufficiency ,renal failure stage and end‐stage re‐nal failure were 44 .44% ,22 .22% ,22 .22% and 11 .11% respectively .The positive warning rates when serum creatinine level was above 133 μmol/L ,increased by 50% compared with the baseline ,increased with 44 μmol/L based on the baseline were 55 .56% , 22 .22% and 22 .22% respectively ,and those positive warning rates in artificial relevance evaluation were 19 .18% ,19 .18% and 56 .54% respectively .Conclusion It is necessary to individualize utilization of vancomycin according to patients′s condition .