继续医学教育
繼續醫學教育
계속의학교육
Continuing Medical Education
2015年
9期
79-81
,共3页
慢性炎症%肿瘤%巨噬细胞%白细胞介素%NF-κB
慢性炎癥%腫瘤%巨噬細胞%白細胞介素%NF-κB
만성염증%종류%거서세포%백세포개소%NF-κB
Chronic inlfammation%Tumor%Macrophage%Interleukin%NF-κB
炎症，尤其是慢性炎症与肿瘤的发生发展有着密切的关系。虽然有些肿瘤与炎症的直接关系尚未确定，但炎症微环境是所有肿瘤发生的必要条件。慢性炎症过程中多种炎症细胞被募集到炎症部位，其分泌不同的细胞因子，如巨噬细胞、炎症细胞因子白细胞介素家族和转录因子NF-κB，参与构成肿瘤微环境，通过复杂的调控机制，在肿瘤生长、浸润和转移过程中发挥重要作用。
炎癥，尤其是慢性炎癥與腫瘤的髮生髮展有著密切的關繫。雖然有些腫瘤與炎癥的直接關繫尚未確定，但炎癥微環境是所有腫瘤髮生的必要條件。慢性炎癥過程中多種炎癥細胞被募集到炎癥部位，其分泌不同的細胞因子，如巨噬細胞、炎癥細胞因子白細胞介素傢族和轉錄因子NF-κB，參與構成腫瘤微環境，通過複雜的調控機製，在腫瘤生長、浸潤和轉移過程中髮揮重要作用。
염증，우기시만성염증여종류적발생발전유착밀절적관계。수연유사종류여염증적직접관계상미학정，단염증미배경시소유종류발생적필요조건。만성염증과정중다충염증세포피모집도염증부위，기분비불동적세포인자，여거서세포、염증세포인자백세포개소가족화전록인자NF-κB，삼여구성종류미배경，통과복잡적조공궤제，재종류생장、침윤화전이과정중발휘중요작용。
Tumor on cogenesis and development are associated with Inflammation, especially chronic inflammation. Although the direct causal relationship between tumor and inflammation is not yet proved, it has become evident that an inflammation microenvironment is an essential component of all tumors. Many inlfammatory cells are recruited to inflammation location, which secret different cytokines. Such as macrophages, interleukins and nuclear factor-κB (NF-κB), which play a critical role in tumor growth, invasion and metastasis regulating by complex mechanism.
