CAJ | 학술논문

目的：分析近20年国内海洋中药研究概况，总结研究热点、特征规律，探讨发展趋势，为海洋中药的临床应用和进一步研发提供数据基础和科学依据。方法：以中国知识基础设施工程（China National Knowledge Infrastructure，CNKI）数据库作为资料来源，用信息计量学方法对相关文献进行分析,并用Cytoscape 3.1.1软件对高频关键词进行关联网络分析。结果：582篇文献纳入分析，2010-2014年5年间发表量达260篇，年均52篇，受各类基金资助的期刊文献266篇，载文最多的杂志是《中国海洋药物》，有278家机构从事相关研究，中国海洋大学是最高产机构，发文量在5篇以上的有12人，海洋药物、化学成分、海洋天然产物、指纹图谱、抗肿瘤等是出现频率较高的关键词。结论：近几年海洋中药研究逐渐成为中药科研领域的热点，研究的主体机构与核心作者群已初步形成。但研究大部分集中在天然产物和药理作用等方面，传统中药理论指导下的海洋中药研究起步较晚，研究基础薄弱，阻碍了海洋中药应拓展的临床应用。应拓展中医古籍文献的知识发现研究，建立海洋中药组方数据库，挖掘海洋中药方剂配伍规律，构建符合海洋中药性效特点的用药经验模式，为临床应用和养生保健提供科学依据。
목적：분석근20년국내해양중약연구개황，총결연구열점、특정규률，탐토발전추세，위해양중약적림상응용화진일보연발제공수거기출화과학의거。방법：이중국지식기출설시공정（China National Knowledge Infrastructure，CNKI）수거고작위자료래원，용신식계량학방법대상관문헌진행분석,병용Cytoscape 3.1.1연건대고빈관건사진행관련망락분석。결과：582편문헌납입분석，2010-2014년5년간발표량체260편，년균52편，수각류기금자조적기간문헌266편，재문최다적잡지시《중국해양약물》，유278가궤구종사상관연구，중국해양대학시최고산궤구，발문량재5편이상적유12인，해양약물、화학성분、해양천연산물、지문도보、항종류등시출현빈솔교고적관건사。결론：근궤년해양중약연구축점성위중약과연영역적열점，연구적주체궤구여핵심작자군이초보형성。단연구대부분집중재천연산물화약리작용등방면，전통중약이론지도하적해양중약연구기보교만，연구기출박약，조애료해양중약응탁전적림상응용。응탁전중의고적문헌적지식발현연구，건립해양중약조방수거고，알굴해양중약방제배오규률，구건부합해양중약성효특점적용약경험모식，위림상응용화양생보건제공과학의거。
This study was aimed to analyze the research status of marine medicine in China. The research hot issues and feature rules were summarized in order to discuss development trends for the clinic application and further development of marine medicine in recent 20 years. The CNKI library was used as a source to retrieve literatures on marine medicine. The bibliometric methods and Cytoscape 3.1.1 were used to analyze. The results showed that 582 papers were included. A total of 260 papers were published during 2010 to 2014. And 52 papers were published annually. 266 papers in this field were funded. The papers were mostly published in theChinese Journal of Marine Drugs. A total of 278 research institutes were engaged in the research. And the institute published the most paper was the Ocean University of China. There were 12 researchers who had published more than 5 articles. This study focused on the keywords with highly frequency, which were marine drugs, chemical composition, marine natural products, fingerprints and antitumor. It was concluded that marine medicine had become hot issues. The core of the group has been formed. However, most researches had focused on natural products and pharmacological aspects. Traditional Chinese medicine (TCM) theory had not been taken seriously and the infrastructure was weak, which obstructed the clinical application of marine medicine. We should expand the discovery and study of knowledge on ancient herbal literature as well as clinic application of marine medicine in order to build the knowledge database of marine medicine and experience mode of clinic application.